GR 89696 fumarate
Highly potent and selective κ-opioid agonist (IC50 = 0.04 nM) that may be selective for the putative κ2 receptor. Anti-nociceptive and neuroprotective in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||13.26||25 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 530.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.89 mL||9.43 mL||18.85 mL|
|5 mM||0.38 mL||1.89 mL||3.77 mL|
|10 mM||0.19 mL||0.94 mL||1.89 mL|
|50 mM||0.04 mL||0.19 mL||0.38 mL|
References are publications that support the biological activity of the product.
Birch et al (1991) Neuroprotective actions of GR89696, a highly potent and selective κ-opioid receptor agonist. Br.J.Pharmacol. 103 1819 PMID: 1657267
Butelman et al (2001) GR89,696: a potent κ-opioid agonist with subtype selectivity in rhesus monkeys. J.Pharmacol.Exp.Ther. 298 1049 PMID: 11504802
Naylor et al (1993) A potent new class of κ-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines. J.Med.Chem. 36 2075 PMID: 8393489
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Keywords: GR 89696 fumarate, GR 89696 fumarate supplier, Subtype-selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, GR89696, fumarate, Kappa, Opioid, 1483, Tocris Bioscience
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Literature in this Area
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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