GR 89696 fumarate

Pricing Availability   Qty
Description: Subtype-selective κ agonist
Chemical Name: 4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for GR 89696 fumarate

GR 89696 fumarate is a highly potent and selective κ-opioid agonist (IC50 = 0.04 nM) that may be selective for the putative κ2 receptor. Anti-nociceptive and neuroprotective in vivo.

Compound Libraries for GR 89696 fumarate

GR 89696 fumarate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GR 89696 fumarate

M. Wt 530.4
Formula C19H25Cl2N3O3.C4H4O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 126766-32-3
PubChem ID 6442840
Smiles [H]OC(=O)\C=C\C(=O)O[H].COC(=O)N1CCN(C(CN2CCCC2)C1)C(=O)CC1=CC=C(Cl)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GR 89696 fumarate

Solvent Max Conc. mg/mL Max Conc. mM
water 13.26 25 with gentle warming
DMSO 53.04 100

Preparing Stock Solutions for GR 89696 fumarate

The following data is based on the product molecular weight 530.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.43 mL 18.85 mL
5 mM 0.38 mL 1.89 mL 3.77 mL
10 mM 0.19 mL 0.94 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets for GR 89696 fumarate

Certificate of Analysis / Product Datasheet
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References for GR 89696 fumarate

References are publications that support the biological activity of the product.

Birch et al (1991) Neuroprotective actions of GR89696, a highly potent and selective κ-opioid receptor agonist. Br.J.Pharmacol. 103 1819 PMID: 1657267

Butelman et al (2001) GR89,696: a potent κ-opioid agonist with subtype selectivity in rhesus monkeys. J.Pharmacol.Exp.Ther. 298 1049 PMID: 11504802

Naylor et al (1993) A potent new class of κ-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines. J.Med.Chem. 36 2075 PMID: 8393489

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Keywords: GR 89696 fumarate, GR 89696 fumarate supplier, Subtype-selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, GR89696, fumarate, Kappa, Opioid, 1483, Tocris Bioscience

Citations for GR 89696 fumarate

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