GR 89696 fumarate

Pricing Availability Delivery Time Qty
Cat.No. 1483 - GR 89696 fumarate | C19H25Cl2N3O3.C4H4O4 | CAS No. 126766-32-3
Description: Subtype-selective κ agonist
Chemical Name: 4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Highly potent and selective κ-opioid agonist (IC50 = 0.04 nM) that may be selective for the putative κ2 receptor. Anti-nociceptive and neuroprotective in vivo.

Technical Data

M. Wt 530.4
Formula C19H25Cl2N3O3.C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 126766-32-3
PubChem ID 6442840
InChI Key ABTNETSDXZBJTE-WLHGVMLRSA-N
Smiles [H]OC(=O)\C=C\C(=O)O[H].COC(=O)N1CCN(C(CN2CCCC2)C1)C(=O)CC1=CC=C(Cl)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.04 100
water 13.26 25mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 530.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.43 mL 18.85 mL
5 mM 0.38 mL 1.89 mL 3.77 mL
10 mM 0.19 mL 0.94 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Birch et al (1991) Neuroprotective actions of GR89696, a highly potent and selective κ-opioid receptor agonist. Br.J.Pharmacol. 103 1819 PMID: 1657267

Butelman et al (2001) GR89,696: a potent κ-opioid agonist with subtype selectivity in rhesus monkeys. J.Pharmacol.Exp.Ther. 298 1049 PMID: 11504802

Naylor et al (1993) A potent new class of κ-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines. J.Med.Chem. 36 2075 PMID: 8393489


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Keywords: Subtype-selective κ-opioid kappa-opioid agonists KOP Receptors OP2 GR89696 fumarate Kappa Opioid Receptors

Citations for GR 89696 fumarate

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