GR 103691

Discontinued Product

GR 103691 (Cat. No. 1109) has been withdrawn from sale for commercial reasons.
Cat.No. 1109 - GR 103691 | C30H35N3O3 | CAS No. 162408-66-4
Description: Highly selective D3 antagonist
Chemical Name: 4'-Acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1'-biphenyl]-4-carboxamide
Datasheet
Citations (5)
Reviews
Literature

Biological Activity

A potent and selective dopamine D3 receptor antagonist, with a Ki value of 0.3 nM and > 100- fold selectivity over D2 and D4 sites.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M. Wt 485.63
Formula C30H35N3O3
Storage Store at RT
CAS Number 162408-66-4
Smiles COC1=CC=CC=C1N1CCN(CCCCNC(=O)C2=CC=C(C=C2)C2=CC=C(C=C2)C(C)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Audinot et al (1998) A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J.Pharmacol.Exp.Ther. 287 187 PMID: 9765337

Hurley et al (1996) Dopamine D3 receptors are not involved in the induction of c-fos mRNA by neuroleptic drugs: comparison of the dopamine D3 receptor antagonist GR 103691 with the typical and atypical neuroleptics. Eur.J.Pharmacol. 318 283 PMID: 9016916

Murray et al (1995) A novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor. Bioorg.Med.Chem.Lett. 5 219

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Keywords: GR 103691, GR 103691 supplier, selective, D3, antagonists, Dopamine, Receptors, dopaminergic, GR103691, GlaxoSmithKline, GSK, 1109, Tocris Bioscience

5 Citations for GR 103691

Citations are publications that use Tocris products. Selected citations for GR 103691 include:

Chen et al (2006) Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J Neurosci 26 2513 PMID: 16510729

Clemens and Hochman (2004) Conversion of the modulatory actions of dopamine on spinal reflexes from depression to facilitation in D3 receptor knock-out mice. J Neurosci 24 11337 PMID: 15601940

Wang et al (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Bone Res 11 2057 PMID: 26649942

Lee et al (2015) Dopaminergic effects on in vitro osteogenesis. Mol Cancer 3 15020 PMID: 26558139

Diaz et al (2014) Moderate Alcohol Exposure during the Rat Equivalent to the Third Trimester of Human Pregnancy Alters Regulation of GABAA Receptor-Mediated Synaptic Transmission by Dopamine in the Basolateral Amygdala. Autophagy 2 46 PMID: 24904907


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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