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Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 490.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||8.15 mL||40.76 mL||81.53 mL|
|1.25 mM||1.63 mL||8.15 mL||16.31 mL|
|2.5 mM||0.82 mL||4.08 mL||8.15 mL|
|12.5 mM||0.16 mL||0.82 mL||1.63 mL|
References are publications that support the biological activity of the product.
Lawrence et al (2002) Effect of metabolic inhibition on glimep. block of native and cloned cardiac sacrolemmal KATP channels. Br.J.Pharmacol. 136 746 PMID: 12086984
If you know of a relevant reference for Glimepiride, please let us know.
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Keywords: Glimepiride, Glimepiride supplier, KATP, channels, openers, Potassium, KIR, Inward, Rectifier, K+, Kir6, Amaryl, Glimperide, rectifier, Channels, 2396, Tocris Bioscience
Citations for Glimepiride
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Reviews for Glimepiride
Average Rating: 5 (Based on 1 Review.)
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In pancreatic beta cells,ATP dependent potassium channels regulate glucose-dependent insulin secretion and serve as the target for sulfonylurea drugs used to treat type 2 diabetes.To understand the role of BK channels on insulin secretion,Glimepiride was used.
Literature in this Area
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