Discontinued Product

Glimepiride (Cat. No. 2396) has been withdrawn from sale for commercial reasons.
Description: Kir6 (KATP) channel blocker
Alternative Names: Amaryl, Glimperide
Chemical Name: 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide
Purity: ≥98% (HPLC)
Reviews (1)

Biological Activity for Glimepiride

Glimepiride is a potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

Technical Data for Glimepiride

M. Wt 490.62
Formula C24H34N4O5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 93479-97-1
PubChem ID 3476
Smiles O=C1C(CC)=C(C)CN1C(NCCC2=CC=C(S(NC(N[C@H]3CC[C@H](C)CC3)=O)(=O)=O)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Glimepiride

References are publications that support the biological activity of the product.

Lawrence et al (2002) Effect of metabolic inhibition on glimep. block of native and cloned cardiac sacrolemmal KATP channels. Br.J.Pharmacol. 136 746 PMID: 12086984

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Keywords: Glimepiride, Glimepiride supplier, KATP, channels, openers, Potassium, KIR, Inward, Rectifier, K+, Kir6, Amaryl, Glimperide, rectifier, Channels, 2396, Tocris Bioscience

Citations for Glimepiride

Citations are publications that use Tocris products.

Currently there are no citations for Glimepiride.

Reviews for Glimepiride

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Glimepiride was used to evaluate the role of BK channel modulation on insulin secretion.
By Anonymous on 11/28/2018
Assay Type: In Vitro
Species: Human

In pancreatic beta cells,ATP dependent potassium channels regulate glucose-dependent insulin secretion and serve as the target for sulfonylurea drugs used to treat type 2 diabetes.To understand the role of BK channels on insulin secretion,Glimepiride was used.

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