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Biological Activity for GC 1
GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.
Compound Libraries for GC 1
Technical Data for GC 1
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GC 1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for GC 1
The following data is based on the product molecular weight 328.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.09 mL||30.45 mL||60.9 mL|
|2.5 mM||1.22 mL||6.09 mL||12.18 mL|
|5 mM||0.61 mL||3.05 mL||6.09 mL|
|25 mM||0.12 mL||0.61 mL||1.22 mL|
References for GC 1
References are publications that support the biological activity of the product.
Chiellini et al (1998) A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor. Chem.Biol. 5 299 PMID: 9653548
Johansson et al (2005) Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc.Natl.Acad.Sci. U S A 102 10297 PMID: 16006512
Columbano et al (2006) The thyroid hormone receptor-β agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology 147 3211 PMID: 16574785
If you know of a relevant reference for GC 1, please let us know.
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Keywords: GC 1, GC 1 supplier, GC1, thryomimetic, high, affinity, thyroid, hormone, receptor, TR, TRalpha, TRbeta, agonists, T3, reverse, cholesterol, transport, hypercholesterolaemia, cellular, proliferation, Sobetirome, Other, Nuclear, Receptors, 4554, Tocris Bioscience
5 Citations for GC 1
Citations are publications that use Tocris products. Selected citations for GC 1 include:
Gonzalez-Hurtado et al (2018) Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing. Mol Metab 7 45 PMID: 29175051
Balboa et al (2018) Ins. mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes. Elife 7 PMID: 30412052
Ning et al (2023) Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death Dis 14 51 PMID: 36681687
Wei et al (2019) Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis. J Hepatol 70 1170-1179 PMID: 30654068
Yao et al (2016) Clobetasol promotes remyelination in a mouse model of neuromyelitis optica. Acta Neuropathol Commun 4 42 PMID: 27117475
Do you know of a great paper that uses GC 1 from Tocris? Please let us know.
Reviews for GC 1
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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