GC 1

Pricing Availability Delivery Time Qty
Cat.No. 4554 - GC 1 | C20H24O4 | CAS No. 211110-63-3
Description: High affinity thyroid receptor α (TRα) and TRβ agonist; thyromimetic
Chemical Name: 2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.

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Technical Data

M. Wt 328.4
Formula C20H24O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 211110-63-3
PubChem ID 9862248
InChI Key QNAZTOHXCZPOSA-UHFFFAOYSA-N
Smiles CC1=CC(OCC(O)=O)=CC(C)=C1CC2=CC(C(C)C)=C(O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.84 100
ethanol 32.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 328.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.23 mL 30.45 mL
5 mM 0.61 mL 3.05 mL 6.09 mL
10 mM 0.3 mL 1.52 mL 3.05 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chiellini et al (1998) A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor. Chem.Biol. 5 299 PMID: 9653548

Johansson et al (2005) Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc.Natl.Acad.Sci. U S A 102 10297 PMID: 16006512

Columbano et al (2006) The thyroid hormone receptor-β agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology 147 3211 PMID: 16574785


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Keywords: GC1 thryomimetic high affinity thyroid hormone receptor TR TRalpha TRbeta agonists T3 reverse cholesterol transport hypercholesterolaemia cellular proliferation Other Nuclear Receptors

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