GC 1

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Description: High affinity thyroid receptor α (TRα) and TRβ agonist; thyromimetic
Alternative Names: Sobetirome
Chemical Name: 2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid
Purity: ≥98% (HPLC)
Citations (5)

Biological Activity for GC 1

GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.

Compound Libraries for GC 1

GC 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GC 1

M. Wt 328.4
Formula C20H24O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 211110-63-3
PubChem ID 9862248
Smiles CC1=CC(OCC(O)=O)=CC(C)=C1CC2=CC(C(C)C)=C(O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GC 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 16.42 50
ethanol 16.42 50

Preparing Stock Solutions for GC 1

The following data is based on the product molecular weight 328.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.09 mL 30.45 mL 60.9 mL
2.5 mM 1.22 mL 6.09 mL 12.18 mL
5 mM 0.61 mL 3.05 mL 6.09 mL
25 mM 0.12 mL 0.61 mL 1.22 mL

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Product Datasheets for GC 1

Certificate of Analysis / Product Datasheet
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References for GC 1

References are publications that support the biological activity of the product.

Chiellini et al (1998) A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor. Chem.Biol. 5 299 PMID: 9653548

Johansson et al (2005) Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc.Natl.Acad.Sci. U S A 102 10297 PMID: 16006512

Columbano et al (2006) The thyroid hormone receptor-β agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology 147 3211 PMID: 16574785

If you know of a relevant reference for GC 1, please let us know.

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Keywords: GC 1, GC 1 supplier, GC1, thryomimetic, high, affinity, thyroid, hormone, receptor, TR, TRalpha, TRbeta, agonists, T3, reverse, cholesterol, transport, hypercholesterolaemia, cellular, proliferation, Sobetirome, Other, Nuclear, Receptors, 4554, Tocris Bioscience

5 Citations for GC 1

Citations are publications that use Tocris products. Selected citations for GC 1 include:

Wei et al (2019) Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis. J Hepatol 70 1170-1179 PMID: 30654068

Gonzalez-Hurtado et al (2018) Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing. Mol Metab 7 45 PMID: 29175051

Ning et al (2023) Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death Dis 14 51 PMID: 36681687

Balboa et al (2018) Ins. mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes. Elife 7 PMID: 30412052

Yao et al (2016) Clobetasol promotes remyelination in a mouse model of neuromyelitis optica. Acta Neuropathol Commun 4 42 PMID: 27117475

Do you know of a great paper that uses GC 1 from Tocris? Please let us know.

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