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GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.
GC 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 328.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.09 mL||30.45 mL||60.9 mL|
|2.5 mM||1.22 mL||6.09 mL||12.18 mL|
|5 mM||0.61 mL||3.05 mL||6.09 mL|
|25 mM||0.12 mL||0.61 mL||1.22 mL|
References are publications that support the biological activity of the product.
Chiellini et al (1998) A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor. Chem.Biol. 5 299 PMID: 9653548
Johansson et al (2005) Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc.Natl.Acad.Sci. U S A 102 10297 PMID: 16006512
Columbano et al (2006) The thyroid hormone receptor-β agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology 147 3211 PMID: 16574785
If you know of a relevant reference for GC 1, please let us know.
Keywords: GC 1, GC 1 supplier, GC1, thryomimetic, high, affinity, thyroid, hormone, receptor, TR, TRalpha, TRbeta, agonists, T3, reverse, cholesterol, transport, hypercholesterolaemia, cellular, proliferation, Sobetirome, Other, Nuclear, Receptors, 4554, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for GC 1 include:
Gonzalez-Hurtado et al (2018) Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing. Mol Metab 7 45 PMID: 29175051
Yao et al (2016) Clobetasol promotes remyelination in a mouse model of neuromyelitis optica. Acta Neuropathol Commun 4 42 PMID: 27117475
Balboa et al (2018) Ins. mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes. Elife 7 PMID: 30412052
Do you know of a great paper that uses GC 1 from Tocris? Please let us know.
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