GBR 13069 dihydrochloride

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Cat.No. 0420 - GBR 13069 dihydrochloride | C28H30F2N2O.2HCl | CAS No. 67469-45-8
Description: Potent dopamine uptake inhibitor
Chemical Name: (1-(2-(Bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
Literature (4)

Biological Activity

A potent inhibitor of dopamine uptake (IC50 = 40 nM). Centrally active following systemic administration in vivo.

Technical Data

M. Wt 521.48
Formula C28H30F2N2O.2HCl
Storage Desiccate at RT
CAS Number 67469-45-8
PubChem ID 24978531
Smiles FC(C=C2)=CC=C2C(OCCN3CCN(C/C=C/C4=CC=CC=C4)CC3)C1=CC=C(F)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 5

Preparing Stock Solutions

The following data is based on the product molecular weight 521.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 38.35 mL 191.76 mL 383.52 mL
0.25 mM 7.67 mL 38.35 mL 76.7 mL
0.5 mM 3.84 mL 19.18 mL 38.35 mL
2.5 mM 0.77 mL 3.84 mL 7.67 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Heikkila et al (1984) Behavioural properties of GBR12909, GBR13069 and GBR13098: specific inhibitors of DA uptake. Eur.J.Pharmacol. 103 241 PMID: 6237922

Mayer et al (1986) Prevention of the nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport. J.Neurochem. 47 1073 PMID: 3489072

Van der Zee and Hespe (1985) Interaction between substituted 1-[2-diphenylmethoxyethyl]piperazines and DA receptors. Neuropharmacology 24 1171 PMID: 4094653

If you know of a relevant reference for GBR 13069 dihydrochloride, please let us know.

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Citations for GBR 13069 dihydrochloride

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