GBR 13069 dihydrochloride

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Cat.No. 0420 - GBR 13069 dihydrochloride | C28H30F2N2O.2HCl | CAS No. 67469-45-8
Description: Potent dopamine uptake inhibitor
Chemical Name: (1-(2-(Bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
Datasheet
Citations
Literature

Biological Activity

A potent inhibitor of dopamine uptake (IC50 = 40 nM). Centrally active following systemic administration in vivo.

Technical Data

M. Wt 521.48
Formula C28H30F2N2O.2HCl
Storage Desiccate at RT
CAS Number 67469-45-8
PubChem ID 24978531
InChI Key ZBSZWEYIIGLGSX-RDRKJGRWSA-N
Smiles FC(C=C2)=CC=C2C(OCCN3CCN(C/C=C/C4=CC=CC=C4)CC3)C1=CC=C(F)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 5 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 521.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.92 mL 9.59 mL 19.18 mL
5 mM 0.38 mL 1.92 mL 3.84 mL
10 mM 0.19 mL 0.96 mL 1.92 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Heikkila et al (1984) Behavioural properties of GBR12909, GBR13069 and GBR13098: specific inhibitors of dopamine uptake. Eur.J.Pharmacol. 103 241 PMID: 6237922

Mayer et al (1986) Prevention of the nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport. J.Neurochem. 47 1073 PMID: 3489072

Van der Zee and Hespe (1985) Interaction between substituted 1-[2-diphenylmethoxyethyl]piperazines and dopamine receptors. Neuropharmacology 24 1171 PMID: 4094653


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Keywords: Potent dopamine reuptake inhibitors inhibits DAT Transporters Monoamine Neurotransmitter GBR13069 dihydrochloride Dopamine Transporters

Citations for GBR 13069 dihydrochloride

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