GBR 12935 dihydrochloride

Discontinued Product

GBR 12935 dihydrochloride (Cat. No. 0514) has been withdrawn from sale for commercial reasons.
Description: Selective dopamine uptake inhibitor
Chemical Name: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
Literature (3)

Biological Activity for GBR 12935 dihydrochloride

GBR 12935 dihydrochloride is a potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).

Technical Data for GBR 12935 dihydrochloride

M. Wt 487.51
Formula C28H34N2O.2HCl
Storage Desiccate at -20°C
CAS Number 67469-81-2
PubChem ID 11957553

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for GBR 12935 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for GBR 12935 dihydrochloride

References are publications that support the biological activity of the product.

Andersen et al (1987) Biochemical and pharmacological characterization of [3H]GBR 12935 binding in vitro to rat striatal membranes: labelling of the DA uptake complex. J.Neurochem. 48 1887 PMID: 2952763

Reith et al (1994) GBR 12909 and 12935 block DA uptake into brain synaptic vesicles as well as nerve endings. Eur.J.Pharmacol. 253 175 PMID: 8013544

Reith et al (1992) Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and DA to the DA transporter. Eur.J.Pharmacol. 227 417 PMID: 1446712

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Citations for GBR 12935 dihydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.