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GBR 12935 dihydrochloride is a potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Andersen et al (1987) Biochemical and pharmacological characterization of [3H]GBR 12935 binding in vitro to rat striatal membranes: labelling of the DA uptake complex. J.Neurochem. 48 1887 PMID: 2952763
Reith et al (1994) GBR 12909 and 12935 block DA uptake into brain synaptic vesicles as well as nerve endings. Eur.J.Pharmacol. 253 175 PMID: 8013544
Reith et al (1992) Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and DA to the DA transporter. Eur.J.Pharmacol. 227 417 PMID: 1446712
Keywords: GBR 12935 dihydrochloride, GBR 12935 dihydrochloride supplier, Selective, dopamine, uptake, inhibitors, inhibits, DAT, Transporters, Monoamine, Neurotransmitter, GBR12935, dihydrochloride, Dopamine, 0514, Tocris Bioscience
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