GBR 12935 dihydrochloride

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Cat.No. 0514 - GBR 12935 dihydrochloride | C28H34N2O.2HCl | CAS No. 67469-81-2
Description: Selective dopamine uptake inhibitor
Chemical Name: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
Literature (4)

Biological Activity

Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).

Technical Data

M. Wt 487.51
Formula C28H34N2O.2HCl
Storage Desiccate at -20°C
CAS Number 67469-81-2
PubChem ID 11957553

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 2.44 5

Preparing Stock Solutions

The following data is based on the product molecular weight 487.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 41.02 mL 205.12 mL 410.25 mL
0.25 mM 8.2 mL 41.02 mL 82.05 mL
0.5 mM 4.1 mL 20.51 mL 41.02 mL
2.5 mM 0.82 mL 4.1 mL 8.2 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Andersen et al (1987) Biochemical and pharmacological characterization of [3H]GBR 12935 binding in vitro to rat striatal membranes: labelling of the DA uptake complex. J.Neurochem. 48 1887 PMID: 2952763

Reith et al (1994) GBR 12909 and 12935 block DA uptake into brain synaptic vesicles as well as nerve endings. Eur.J.Pharmacol. 253 175 PMID: 8013544

Reith et al (1992) Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and DA to the DA transporter. Eur.J.Pharmacol. 227 417 PMID: 1446712

If you know of a relevant reference for GBR 12935 dihydrochloride, please let us know.

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