Galiellalactone

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Cat.No. 6218 - Galiellalactone | C11H14O3 | CAS No. 133613-71-5
Description: STAT3 inhibitor; active in vivo
Chemical Name: (4S,5aR,7aR,7bS)-5,5a,6,7,7a,7b-Hexahydro-7b-hydroxy-4-methylindeno[1,7-bc]furan-2(4H)-one
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

STAT3 inhibitor. Irreversibly binds STAT3 and inhibits binding to DNA. Inhibits IL-6-dependent JAK/STAT signaling. Induces cell-cycle arrest in G2/M phase and apoptosis in androgen-insensitive prostate cancer cells via activation of ATM/ATR pathway. Also destabilizes microtubules and inhibits cell migration. Exhibits anticancer effects in a mouse tumor xenograft model.

Technical Data

M. Wt 194.23
Formula C11H14O3
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 133613-71-5
PubChem ID 3698011
InChI Key SOIISBQQYAGDKM-UHFFFAOYSA-N
Smiles [H][C@@]12CC[C@]3(OC(C([C@@]23O)=C[C@H](C1)C)=O)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.97 5
ethanol 0.97 5

Preparing Stock Solutions

The following data is based on the product molecular weight 194.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 102.97 mL 514.85 mL 1029.71 mL
0.25 mM 20.59 mL 102.97 mL 205.94 mL
0.5 mM 10.3 mL 51.49 mL 102.97 mL
2.5 mM 2.06 mL 10.3 mL 20.59 mL

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References

References are publications that support the biological activity of the product.

Don-Doncow et al (2014) Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. J.Biol.Chem. 289 15969 PMID: 24755219

Weilder et al (2000) Inhibition of interleukin-6 signaling by galiellalactone. FEBS Lett. 484 1 PMID: 11056211

Garcia et al (2016) Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells. Oncotarget 7 4490 PMID: 26683224


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Citations for Galiellalactone

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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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  • Epigenetics in Cancer
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Pathways for Galiellalactone

JAK-STAT

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.