FX 1

Pricing Availability   Qty
Description: Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
Chemical Name: (5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinepropanoic acid
Purity: ≥98% (HPLC)
Literature (2)
Pathways (1)

Biological Activity for FX 1

FX 1 is a Bcl-6 inhibitor (Kd = 3 μM); exhibits 10-fold greater potency than endogenous Bcl-6 corepressors. Disrupts formation of Bcl-6 repression complex. Induces regression of established tumors in mice bearing DLBCL xenograft.

Technical Data for FX 1

M. Wt 368.82
Formula C14H9ClN2O4S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1426138-42-2
PubChem ID 66488970
Smiles OC(CCN1C(S/C(C1=O)=C2C(NC3=CC=C(C=C\23)Cl)=O)=S)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FX 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.88 100

Preparing Stock Solutions for FX 1

The following data is based on the product molecular weight 368.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.56 mL 27.11 mL
5 mM 0.54 mL 2.71 mL 5.42 mL
10 mM 0.27 mL 1.36 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References for FX 1

References are publications that support the biological activity of the product.

Cardenas et al (2016) Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma. J.Clin.Invest. 126 3351 PMID: 27482887

Cardenas et al (2017) The expanding role of the BCL6 oncoprotein as a cancer therapeutic target. Clin.Cancer Res. 23 885 PMID: 27881582

If you know of a relevant reference for FX 1, please let us know.

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Citations for FX 1

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Pathways for FX 1

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Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.