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Biological Activity for FX 1
FX 1 is a Bcl-6 inhibitor (Kd = 3 μM); exhibits 10-fold greater potency than endogenous Bcl-6 corepressors. Disrupts formation of Bcl-6 repression complex. Induces regression of established tumors in mice bearing DLBCL xenograft.
Technical Data for FX 1
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FX 1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for FX 1
The following data is based on the product molecular weight 368.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.71 mL||13.56 mL||27.11 mL|
|5 mM||0.54 mL||2.71 mL||5.42 mL|
|10 mM||0.27 mL||1.36 mL||2.71 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References for FX 1
References are publications that support the biological activity of the product.
Cardenas et al (2016) Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma. J.Clin.Invest. 126 3351 PMID: 27482887
Cardenas et al (2017) The expanding role of the BCL6 oncoprotein as a cancer therapeutic target. Clin.Cancer Res. 23 885 PMID: 27881582
If you know of a relevant reference for FX 1, please let us know.
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Citations for FX 1
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.