Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) symporter. Also acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 330.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.02 mL||15.12 mL||30.24 mL|
|5 mM||0.6 mL||3.02 mL||6.05 mL|
|10 mM||0.3 mL||1.51 mL||3.02 mL|
|50 mM||0.06 mL||0.3 mL||0.6 mL|
References are publications that support the products' biological activity.
Thompson et al (1999) Residues in transmembrane domains I and II determine γ-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide. Mol.Pharmacol. 55 993 PMID: 10347239
Gutschmidt et al (1999) Anticonvulsant actions of furosemide in vitro. Neuroscience 91 1471 PMID: 10391452
If you know of a relevant reference for Furosemide, please let us know.
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Keywords: Furosemide, supplier, Na+/2Cl-/K+, NKCC1, NKCC2, cotransporters, inhibitors, inhibits, antagonizes, GABAA, receptor, antagonists, blockers, Sodium, Potassium, Chloride, Ion, Transporters, Pumps, Receptors, diuretics, Na+/K+/Cl-, Symporter, GABAA, Receptors, Na+/K+/Cl-, Symporter, Tocris Bioscience
2 Citations for Furosemide
Citations are publications that use Tocris products. Selected citations for Furosemide include:
Choe et al (2015) High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Autophagy 85 549 PMID: 25619659
Barbaro (2017) Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension. Cell Rep 21 1009 PMID: 29069584
Do you know of a great paper that uses Furosemide from Tocris? If so please let us know.
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