Furosemide

Pricing Availability Delivery Time Qty
Cat.No. 3109 - Furosemide | C12H11ClN2O5S | CAS No. 54-31-9
Description: Na+/2Cl-/K+ (NKCC) symporter inhibitor. Also antagonizes GABAA
Chemical Name: 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) symporter. Also acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.

Compound Libraries

Furosemide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 330.74
Formula C12H11ClN2O5S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 54-31-9
PubChem ID 3440
InChI Key ZZUFCTLCJUWOSV-UHFFFAOYSA-N
Smiles ClC1=CC(NCC2=CC=CO2)=C(C(O)=O)C=C1S(=O)(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.07 100

Preparing Stock Solutions

The following data is based on the product molecular weight 330.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.12 mL 30.24 mL
5 mM 0.6 mL 3.02 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Thompson et al (1999) Residues in transmembrane domains I and II determine γ-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide. Mol.Pharmacol. 55 993 PMID: 10347239

Gutschmidt et al (1999) Anticonvulsant actions of furosemide in vitro. Neuroscience 91 1471 PMID: 10391452


If you know of a relevant reference for Furosemide, please let us know.

View Related Products by Product Action

View all Na+/K+/Cl- Symporter Inhibitors

Keywords: Furosemide, supplier, Na+/2Cl-/K+, NKCC1, NKCC2, cotransporters, inhibitors, inhibits, antagonizes, GABAA, receptor, antagonists, blockers, Sodium, Potassium, Chloride, Ion, Transporters, Pumps, Receptors, diuretics, Na+/K+/Cl-, Symporter, GABAA, Receptors, Na+/K+/Cl-, Symporter, Tocris Bioscience

2 Citations for Furosemide

Citations are publications that use Tocris products. Selected citations for Furosemide include:

Barbaro (2017) Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension. Cell Rep 21 1009 PMID: 29069584

Choe et al (2015) High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Autophagy 85 549 PMID: 25619659


Do you know of a great paper that uses Furosemide from Tocris? If so please let us know.

Furosemide Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used Furosemide?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure