Furosemide

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Cat.No. 3109 - Furosemide | C12H11ClN2O5S | CAS No. 54-31-9
Description: Na+/2Cl-/K+ (NKCC) symporter inhibitor; also GABAA antagonist
Chemical Name: 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (1)

Biological Activity

Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) symporter. Also acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.

Compound Libraries

Furosemide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 330.74
Formula C12H11ClN2O5S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 54-31-9
PubChem ID 3440
InChI Key ZZUFCTLCJUWOSV-UHFFFAOYSA-N
Smiles ClC1=CC(NCC2=CC=CO2)=C(C(O)=O)C=C1S(=O)(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.07 100

Preparing Stock Solutions

The following data is based on the product molecular weight 330.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.12 mL 30.24 mL
5 mM 0.6 mL 3.02 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Thompson et al (1999) Residues in transmembrane domains I and II determine γ-aminobutyric acid type AA receptor subtype-selective antagonism by Furos.. Mol.Pharmacol. 55 993 PMID: 10347239

Gutschmidt et al (1999) Anticonvulsant actions of Furos. in vitro. Neuroscience 91 1471 PMID: 10391452


If you know of a relevant reference for Furosemide, please let us know.

View Related Products by Product Action

View all Na+/K+/Cl- Symporter Inhibitors

Keywords: Furosemide, Furosemide supplier, Na+/2Cl-/K+, NKCC1, NKCC2, cotransporters, inhibitors, inhibits, antagonizes, GABAA, receptor, antagonists, blockers, Sodium, Potassium, Chloride, Ion, Transporters, Pumps, Receptors, diuretics, Na+/K+/Cl-, Symporter, 3109, Tocris Bioscience

6 Citations for Furosemide

Citations are publications that use Tocris products. Selected citations for Furosemide include:

Barbaro (2017) Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension. Cell Rep 21 1009 PMID: 29069584

Accardi et al (2015) α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Ins in Cerebellar Granule Cells. J Neurosci 35 9676 PMID: 26134650

Li et al (2017) Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity. Cell 168 86 PMID: 27916275

Choe et al (2015) High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Autophagy 85 549 PMID: 25619659

Angelantonio et al (2014) A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium. Cell Death Dis 5 e1501 PMID: 25356870

Deeb et al (2013) Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of D.pam during hyperexcited states. Eur J Neurosci 38 2453 PMID: 23627375


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