FR 236924

Pricing Availability Delivery Time Qty
Cat.No. 3091 - FR 236924 | C20H36O2 | CAS No. 28399-31-7
Description: Selective PKCε activator
Alternative Names: DCP-LA
Chemical Name: 2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective PKCε activator that displays > 7-fold selectivity over other PKC isozymes. Stimulates glutamate release via presynaptic α7 nicotinic receptors on glutamatergic terminals in vitro and enhances cognition in vivo. Brain penetrant.

Technical Data

M. Wt 308.5
Formula C20H36O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 28399-31-7
PubChem ID 9904718
InChI Key CONYTTFKIUJZOF-UHFFFAOYSA-N
Smiles CCCCCC(C2)C2CC1C(CCCCCCCC(O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.85 100
ethanol 30.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 308.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.21 mL 32.41 mL
5 mM 0.65 mL 3.24 mL 6.48 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Yamamoto et al (2005) The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancgng activity of presynaptic α7 acetylcholine receptors on the glutamatergic terminals. Neuroscience 130 207 PMID: 15561436

Kanno et al (2006) The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding site. J.Lipid Res. 47 1146 PMID: 16520488

Tanaka and Nishizaki (2003) The newly synthesized linoleic acid derivative FR236924 induces a long lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. Bioorg.Med.Chem.Letts. 13 1037 PMID:


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Keywords: FR 236924, supplier, pkc, pkce, epsilon, protein, kinase, c, a7, α7, alpha7, nAChR, nicotinic, acetylycholine, receptor, ACh, FR236924, DCP-LA, Protein, Kinase, C, Tocris Bioscience

Citations for FR 236924

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