FR 236924

Discontinued Product

FR 236924 (Cat. No. 3091) has been withdrawn from sale for commercial reasons.
Cat.No. 3091 - FR 236924 | C20H36O2 | CAS No. 28399-31-7
Description: Selective PKCε activator
Alternative Names: DCP-LA
Chemical Name: 2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Selective PKCε activator that displays > 7-fold selectivity over other PKC isozymes. Stimulates glutamate release via presynaptic α7 nicotinic receptors on glutamatergic terminals in vitro and enhances cognition in vivo. Brain penetrant.

Technical Data

M. Wt 308.5
Formula C20H36O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 28399-31-7
PubChem ID 9904718
InChI Key CONYTTFKIUJZOF-UHFFFAOYSA-N
Smiles CCCCCC(C2)C2CC1C(CCCCCCCC(O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Yamamoto et al (2005) The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancgng activity of presynaptic α7 acetylcholine receptors on the glutamatergic terminals. Neuroscience 130 207 PMID: 15561436

Kanno et al (2006) The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding site. J.Lipid Res. 47 1146 PMID: 16520488

Tanaka and Nishizaki (2003) The newly synthesized linoleic acid derivative FR236924 induces a long lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. Bioorg.Med.Chem.Letts. 13 1037

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Keywords: FR 236924, FR 236924 supplier, pkc, pkce, epsilon, protein, kinase, c, a7, α7, alpha7, nAChR, nicotinic, acetylycholine, receptor, ACh, FR236924, DCP-LA, Protein, Kinase, C, Nicotinic, (a7), Receptors, 3091, Tocris Bioscience

Citations for FR 236924

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Currently there are no citations for FR 236924.

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Literature in this Area

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