Fostriecin sodium salt

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Cat.No. 1840 - Fostriecin sodium salt | C19H26O9PNa | CAS No. 87860-39-7
Description: Potent PP2A and PP4 inhibitor
Chemical Name: (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews (1)
Literature

Biological Activity

Potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo. Originally identified as an antitumor antibiotic from Streptomyces pulveraceous.

Technical Data

M. Wt 452.37
Formula C19H26O9PNa
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 87860-39-7
PubChem ID 16759606
InChI Key XBUIKNRVGYFSHL-IAVQPKKASA-M
Smiles [Na+].C[C@@](O)(\C=C\[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)\C=C/C=C\C=C\CO)OP(O)([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 45.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 452.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.05 mL 22.11 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.11 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Tunac et al (1983) Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties. J.Antibiot. 36 1595 PMID: 6689323

Walsh et al (1997) Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. FEBS Lett. 416 230 PMID: 9373158

Hastie and Cohen (1998) Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters. FEBS Lett. 431 357 PMID: 9714542


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Keywords: Fostriecin sodium salt, Fostriecin sodium salt supplier, Potent, PP2A, PP4, inhibitors, inhibits, Calcineurin, Protein, Ser/Thr, protein, phosphatases, 2A, 4, antibiotics, Phosphatases, Antibiotics, 1840, Tocris Bioscience

5 Citations for Fostriecin sodium salt

Citations are publications that use Tocris products. Selected citations for Fostriecin sodium salt include:

Xu et al (2010) Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant. J Neurosci 115 1643 PMID: 20969573

Goffin et al (2010) Dopamine-dependent tuning of striatal inhibitory synaptogenesis. J Neurosci 30 2935 PMID: 20181591

Chen et al (2014) Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential regulat J Neurosci 34 9621 PMID: 25031403

Pribiag and Stellwagen (2013) TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors. J Neurosci 33 15879 PMID: 24089494

Xu et al (2009) Hyperdopaminergic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate. J Neurosci 29 14086 PMID: 19906957


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Reviews for Fostriecin sodium salt

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PP2A dependent dephosphorylation of an enzyme
By Anonymous on 12/04/2017
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Rat chondrosarcoma (RCS) cells

I used fostriecin to investigate the contribution of PP2A to dephosphorylation of my enzyme. I preincubated cells with fostriecin and assayed for enzyme activity.


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