Fluvoxamine maleate

Pricing Availability   Qty
Description: 5-HT reuptake inhibitor
Chemical Name: (E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-O-(2-aminoethyl)oxime maleate
Purity: ≥99%
Citations (8)
Literature (1)

Biological Activity for Fluvoxamine maleate

Fluvoxamine maleate is a selective serotonin reuptake inhibitor; antidepressant. Binds to the human 5-HT transporter with a Ki of 1.6 nmol/l.

Technical Data for Fluvoxamine maleate

M. Wt 434.41
Formula C15H21F3N2O2.C4H4O4
Storage Desiccate at +4°C
Purity ≥99%
CAS Number 61718-82-9
PubChem ID 9560989
Smiles OC(=O)\C=C/C(O)=O.COCCCC\C(C1=CC=C(C=C1)C(F)(F)F)=N/OCCN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Fluvoxamine maleate

Solvent Max Conc. mg/mL Max Conc. mM
water 4.34 10

Preparing Stock Solutions for Fluvoxamine maleate

The following data is based on the product molecular weight 434.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.02 mL 115.1 mL 230.2 mL
0.5 mM 4.6 mL 23.02 mL 46.04 mL
1 mM 2.3 mL 11.51 mL 23.02 mL
5 mM 0.46 mL 2.3 mL 4.6 mL

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Product Datasheets for Fluvoxamine maleate

Certificate of Analysis / Product Datasheet
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References for Fluvoxamine maleate

References are publications that support the biological activity of the product.

Benfield and Ward (1986) Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 32 313 PMID: 3096686

Classen et al (1977) Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor. Br.J.Pharmacol. 60 505 PMID: 302726

Narita et al (1996) Interactions of selective serotonin reuptake inhibitors with subtypes of σ receptors in rat brain. Eur.J.Pharmacol. 307 117 PMID: 8831113

Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305 PMID: 9400006

If you know of a relevant reference for Fluvoxamine maleate, please let us know.

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Keywords: Fluvoxamine maleate, Fluvoxamine maleate supplier, High, affinity, σ1, sigma1, ligands, 5-HT, reuptake, inhibitors, inhibits, Receptors, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, Sigma1, 1033, Tocris Bioscience

8 Citations for Fluvoxamine maleate

Citations are publications that use Tocris products. Selected citations for Fluvoxamine maleate include:

Agarwal et al (2013) TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity. World J Gastroenterol 8 e63028 PMID: 23667566

Wood et al (2011) Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production. J Neurosci 31 13808 PMID: 21957243

Su et al (2014) Effects of BD1047, a σ1 receptor antagonist, on the expression of mTOR, Camk2γ and GSK-3β in fluvoxamine-treated N2a cells. PLoS One 7 435 PMID: 24396420

Fishback et al (2012) A 96-well filtration method for radioligand binding analysis of σ receptor ligands. J Pharm Biomed Anal 71 157 PMID: 22910107

Do you know of a great paper that uses Fluvoxamine maleate from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.