Fluvoxamine maleate

Pricing Availability Delivery Time Qty
Cat.No. 1033 - Fluvoxamine maleate | C15H21F3N2O2.C4H4O4 | CAS No. 61718-82-9
Description: 5-HT re-uptake inhibitor
Chemical Name: (E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-O-(2-aminoethyl)oxime maleate
Purity: ≥99%
Datasheet
Citations (5)
Reviews
Literature

Biological Activity

Selective serotonin reuptake inhibitor; antidepressant. Binds to the human 5-HT transporter with a Ki of 1.6 nmol/l.

Technical Data

M. Wt 434.41
Formula C15H21F3N2O2.C4H4O4
Storage Desiccate at +4°C
Purity ≥99%
CAS Number 61718-82-9
PubChem ID 9560989
InChI Key LFMYNZPAVPMEGP-PIDGMYBPSA-N
Smiles OC(=O)\C=C/C(O)=O.COCCCC\C(C1=CC=C(C=C1)C(F)(F)F)=N/OCCN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.34 10

Preparing Stock Solutions

The following data is based on the product molecular weight 434.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.51 mL 23.02 mL
5 mM 0.46 mL 2.3 mL 4.6 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Benfield and Ward (1986) Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 32 313 PMID: 3096686

Classen et al (1977) Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor. Br.J.Pharmacol. 60 505 PMID: 302726

Narita et al (1996) Interactions of selective serotonin reuptake inhibitors with subtypes of σ receptors in rat brain. Eur.J.Pharmacol. 307 117 PMID: 8831113

Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305 PMID: 9400006


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5 Citations for Fluvoxamine maleate

Citations are publications that use Tocris products. Selected citations for Fluvoxamine maleate include:

Wood et al (2011) Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production. J Neurosci 31 13808 PMID: 21957243

Hirano et al (2005) Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitors. Br J Pharmacol 144 695 PMID: 15678084

Su et al (2014) Effects of BD1047, a σ1 receptor antagonist, on the expression of mTOR, Camk2γ and GSK-3β in fluvoxamine-treated N2a cells. PLoS One 7 435 PMID: 24396420

Agarwal et al (2013) TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity. World J Gastroenterol 8 e63028 PMID: 23667566

O'Donnell et al (2010) The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. PLoS One 5 PMID: 20957046


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