FK 409

Description: NO donor
Alternative Names: NOR-3, (±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
Chemical Name: (2E,3E)-4-Ethyl-2-(hydroxyimino)-5-nitro-3-hexenamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity

NO donor; exhibits vasorelaxant (EC50 = 3.9 nM) and antiplatelet activities (IC50 = 4.9 μM). Cell permeable.

Technical Data

M. Wt 215.21
Formula C8H13N3O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 138472-01-2
PubChem ID 6437875
InChI Key MZAGXDHQGXUDDX-AGLLBGTNSA-N
Smiles CC(/C(CC)=C/C(C(N)=O)=N\O)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Fukuyama et al (1997) Structure-activity relationships of spontaneous nitric oxide releasers, FK409 and its derivatives. J.Pharmacol.Exp.Ther. 282 236 PMID: 9223559

Keywords: FK 409, FK 409 supplier, FK409, NO, donors, nitric, oxide, vasorelaxant, cell, permeable, NOR-3, (±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide, Donors, /, Precursors, ROS, 3105, Tocris Bioscience

1 Citation for FK 409

Citations are publications that use Tocris products. Selected citations for FK 409 include:

Cortés-Montero et al (2019) The axonal motor neuropathy-related HINT1 protein is a zinc- and calmodulin-regulated cysteine SUMO protease. Antioxid Redox Signal PMID: 31088288


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Literature in this Area

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