FK 409

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Cat.No. 3105 - FK 409 | C8H13N3O4 | CAS No. 138472-01-2
Description: NO donor
Alternative Names: NOR-3, (±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
Chemical Name: (2E,3E)-4-Ethyl-2-(hydroxyimino)-5-nitro-3-hexenamide
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity

NO donor; exhibits vasorelaxant (EC50 = 3.9 nM) and antiplatelet activities (IC50 = 4.9 μM). Cell permeable.

Technical Data

M. Wt 215.21
Formula C8H13N3O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 138472-01-2
PubChem ID 6437875
Smiles CC(/C(CC)=C/C(C(N)=O)=N\O)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.52 100
ethanol 21.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 215.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.65 mL 23.23 mL 46.47 mL
5 mM 0.93 mL 4.65 mL 9.29 mL
10 mM 0.46 mL 2.32 mL 4.65 mL
50 mM 0.09 mL 0.46 mL 0.93 mL

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References are publications that support the biological activity of the product.

Fukuyama et al (1997) Structure-activity relationships of spontaneous nitric oxide releasers, FK409 and its derivatives. J.Pharmacol.Exp.Ther. 282 236 PMID: 9223559

If you know of a relevant reference for FK 409, please let us know.

Keywords: FK 409, FK 409 supplier, FK409, NO, donors, nitric, oxide, vasorelaxant, cell, permeable, NOR-3, (±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide, Donors, /, Precursors, ROS, 3105, Tocris Bioscience

1 Citation for FK 409

Citations are publications that use Tocris products. Selected citations for FK 409 include:

Cortés-Montero et al (2019) The axonal motor neuropathy-related HINT1 protein is a zinc- and calmodulin-regulated cysteine SUMO protease. Antioxid Redox Signal PMID: 31088288

Do you know of a great paper that uses FK 409 from Tocris? Please let us know.

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Literature in this Area

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