Nitric oxide donor. Activates an inward current in cultured rat cerebellar granules cells. Increases cGMP production in cultured vascular smooth muscle cells. Reduces contractility of cardiac muscle preparations in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 163.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.13 mL||30.64 mL||61.28 mL|
|5 mM||1.23 mL||6.13 mL||12.26 mL|
|10 mM||0.61 mL||3.06 mL||6.13 mL|
|50 mM||0.12 mL||0.61 mL||1.23 mL|
References are publications that support the biological activity of the product.
Thompson et al (2009) The NO donor DETA-NONOate reversibly activates an inward current in neurones and is not mediated by the released nitric oxide. Br.J.Pharmacol. 158 1338 PMID: 19785659
Olson et al (1997) Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation. Hypertension 29 254 PMID: 9039111
Wegener et al (2002) Effects of nitric oxide donors on cardiac contractility in wild-type and myoglobin-deficient mice. Br.J.Pharmacol. 136 415 PMID: 12023944
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Keywords: DETA NONOate, DETA NONOate supplier, nitric, oxide, releasing, compounds, donors, NO, Donors, /, Precursors, ROS, 6077, Tocris Bioscience
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