Discontinued Product

DETA NONOate (Cat. No. 6077) has been withdrawn from sale for commercial reasons.
Description: Nitric oxide donor
Chemical Name: 2,2'-(2-Hydroxy-2-nitrosohydrazinylidene)bis-ethanamine

Biological Activity for DETA NONOate

Nitric oxide donor. Activates an inward current in cultured rat cerebellar granules cells. Increases cGMP production in cultured vascular smooth muscle cells. Reduces contractility of cardiac muscle preparations in vitro.

Technical Data for DETA NONOate

M. Wt 163.18
Formula C4H13N5O2
Storage Store at -20°C
CAS Number 146724-94-9
PubChem ID 1606

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for DETA NONOate

Certificate of Analysis / Product Datasheet
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References for DETA NONOate

References are publications that support the biological activity of the product.

Thompson et al (2009) The NO donor DETA-NONOate reversibly activates an inward current in neurones and is not mediated by the released nitric oxide. Br.J.Pharmacol. 158 1338 PMID: 19785659

Olson et al (1997) Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation. Hypertension 29 254 PMID: 9039111

Wegener et al (2002) Effects of nitric oxide donors on cardiac contractility in wild-type and myoglobin-deficient mice. Br.J.Pharmacol. 136 415 PMID: 12023944

Keywords: DETA NONOate, DETA NONOate supplier, nitric, oxide, releasing, compounds, donors, NO, Donors, /, Precursors, ROS, 6077, Tocris Bioscience

Citations for DETA NONOate

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Currently there are no citations for DETA NONOate.

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