DETA NONOate

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Cat.No. 6077 - DETA NONOate | C4H13N5O2 | CAS No. 146724-94-9
Description: Nitric oxide donor
Chemical Name: 2,2'-(2-Hydroxy-2-nitrosohydrazinylidene)bis-ethanamine
Datasheet
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Literature

Biological Activity

Nitric oxide donor. Activates an inward current in cultured rat cerebellar granules cells. Increases cGMP production in cultured vascular smooth muscle cells. Reduces contractility of cardiac muscle preparations in vitro.

Technical Data

M. Wt 163.18
Formula C4H13N5O2
Storage Store at -20°C
CAS Number 146724-94-9
PubChem ID 1606
InChI Key HMRRJTFDJAVRMR-UHFFFAOYSA-N
Smiles NCCN(N(N=O)O)CCN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 16.32 100

Preparing Stock Solutions

The following data is based on the product molecular weight 163.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.13 mL 30.64 mL 61.28 mL
5 mM 1.23 mL 6.13 mL 12.26 mL
10 mM 0.61 mL 3.06 mL 6.13 mL
50 mM 0.12 mL 0.61 mL 1.23 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Thompson et al (2009) The NO donor DETA-NONOate reversibly activates an inward current in neurones and is not mediated by the released nitric oxide. Br.J.Pharmacol. 158 1338 PMID: 19785659

Olson et al (1997) Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation. Hypertension 29 254 PMID: 9039111

Wegener et al (2002) Effects of nitric oxide donors on cardiac contractility in wild-type and myoglobin-deficient mice. Br.J.Pharmacol. 136 415 PMID: 12023944


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Keywords: DETA NONOate, DETA NONOate supplier, nitric, oxide, releasing, compounds, donors, NO, Donors, /, Precursors, ROS, 6077, Tocris Bioscience

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