You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for FITC-labelled Keap1-Nrf2 probe
FITC-labelled Keap1-Nrf2 probe is a fluorescent Keap1-Nrf2 peptide (Kd = 22.3 nM). It can be used to assess the binding affinities of Nrf2 peptide inhibitors in Fluorescence Polarization (FP) displacement assay.
Technical Data for FITC-labelled Keap1-Nrf2 probe
(Modifications: Leu-1 = FITC-Leu, Leu-9 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FITC-labelled Keap1-Nrf2 probe
|Solubility||Soluble to 2 mg/ml in PBS|
Product Datasheets for FITC-labelled Keap1-Nrf2 probe
References for FITC-labelled Keap1-Nrf2 probe
References are publications that support the biological activity of the product.
Chen et al (2011) Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance. Chem.Biol.Drug Des. 78 1014 PMID: 21920027
Inoyama et al (2012) Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction. J.Biomol.Screen 17 435 PMID: 22156223
Wang et al (2020) Development of an enzyme-linked immunosorbent assay for Keap1-Nrf2 interaction inhibitors identification. Redox Biol. 34 101573 PMID: 32422542
If you know of a relevant reference for FITC-labelled Keap1-Nrf2 probe, please let us know.
View Related Products by Target
Keywords: FITC-labelled Keap1-Nrf2 probe, FITC-labelled Keap1-Nrf2 probe supplier, Fluorescent, Fluorescence, polarization, FP, displacement, assays, Keap1, Nrf2, ARE, pathway, peptide, transcription, factor, Ubiquitin, E3, Ligases, Enzyme, Probes, and, Substrates, 7627, Tocris Bioscience
Citations for FITC-labelled Keap1-Nrf2 probe
Citations are publications that use Tocris products.
Currently there are no citations for FITC-labelled Keap1-Nrf2 probe. Do you know of a great paper that uses FITC-labelled Keap1-Nrf2 probe from Tocris? Please let us know.
Reviews for FITC-labelled Keap1-Nrf2 probe
There are currently no reviews for this product. Be the first to review FITC-labelled Keap1-Nrf2 probe and earn rewards!
Have you used FITC-labelled Keap1-Nrf2 probe?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Targeted Protein Degradation Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Ubiquitin-Proteasome System Proteins
- Assays for Protein Degradation
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia