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Biological Activity for FITC-labelled Keap1-Nrf2 probe
FITC-labelled Keap1-Nrf2 probe is a fluorescent Keap1-Nrf2 peptide (Kd = 22.3 nM). It can be used to assess the binding affinities of Nrf2 peptide inhibitors in Fluorescence Polarization (FP) displacement assays and TR-FRET.
Optical Data for FITC-labelled Keap1-Nrf2 probe
|Closest Laser line||488 nm|
|Application||Fluorescence polarization (FP) displacement assays, TR-FRET|
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.Spectral Viewer
Technical Data for FITC-labelled Keap1-Nrf2 probe
(Modifications: Leu-1 = FITC-Leu, Leu-9 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FITC-labelled Keap1-Nrf2 probe
|Solubility||Soluble to 2 mg/ml in PBS|
Product Datasheets for FITC-labelled Keap1-Nrf2 probe
References for FITC-labelled Keap1-Nrf2 probe
References are publications that support the biological activity of the product.
Chen et al (2011) Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance. Chem.Biol.Drug Des. 78 1014 PMID: 21920027
Inoyama et al (2012) Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction. J.Biomol.Screen 17 435 PMID: 22156223
Wang et al (2020) Development of an enzyme-linked immunosorbent assay for Keap1-Nrf2 interaction inhibitors identification. Redox Biol. 34 101573 PMID: 32422542
If you know of a relevant reference for FITC-labelled Keap1-Nrf2 probe, please let us know.
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Keywords: FITC-labelled Keap1-Nrf2 probe, FITC-labelled Keap1-Nrf2 probe supplier, Fluorescent, Fluorescence, polarization, FP, displacement, assays, Keap1, Nrf2, ARE, pathway, peptide, transcription, factor, TR-FRET, Ubiquitin, E3, Ligases, Enzyme, Probes, and, Substrates, Assay, Reagents, 7627, Tocris Bioscience
Citations for FITC-labelled Keap1-Nrf2 probe
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