FIN 56

Pricing Availability   Qty
Cat.No. 6280 - FIN 56 | C25H31N3O5S2 | CAS No. 1083162-61-1
Description: Ferroptosis activator
Chemical Name: N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Bifunctional inducer of ferroptosis in vitro. Activates squalene synthase (SQS) leading to coenzyme Q10 depletion. Also induces degradation of glutathione peroxidase 4 (GPX4), via acetyl-CoA carboxylase (ACC).

Technical Data

M. Wt 517.66
Formula C25H31N3O5S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1083162-61-1
Smiles ON=C1C2=CC(=CC=C2C2=CC=C(C=C12)S(=O)(=O)NC1CCCCC1)S(=O)(=O)NC1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.77 100

Preparing Stock Solutions

The following data is based on the product molecular weight 517.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.66 mL 19.32 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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References

References are publications that support the biological activity of the product.

Shimada et al (2016) Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat.Chem.Biol. 12 497 PMID: 27159577

Cotto-Rios and Gavathiotis (2016) Chemical genetics: Unraveling cell death mysteries. Nat.Chem.Biol. 12 470 PMID: 27315536


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Keywords: FIN 56, FIN 56 supplier, FIN56, glutathione, peroxidase, 4, GPX4, activates, ferroptosis, activators, squalene, synthase, acetyl-CoA, carboxylase, ACC, Ferroptosis, Enzyme, Substrates, /, Activators, 6280, Tocris Bioscience

Citations for FIN 56

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Pathways for FIN 56

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.