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Biological Activity for FIN 56
FIN 56 is a bifunctional inducer of ferroptosis in vitro. Activates squalene synthase (SQS) leading to coenzyme Q10 depletion. Also induces degradation of glutathione peroxidase 4 (GPX4), via acetyl-CoA carboxylase (ACC).
Compound Libraries for FIN 56
Technical Data for FIN 56
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FIN 56
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for FIN 56
The following data is based on the product molecular weight 517.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.93 mL||9.66 mL||19.32 mL|
|5 mM||0.39 mL||1.93 mL||3.86 mL|
|10 mM||0.19 mL||0.97 mL||1.93 mL|
|50 mM||0.04 mL||0.19 mL||0.39 mL|
References for FIN 56
References are publications that support the biological activity of the product.
Shimada et al (2016) Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat.Chem.Biol. 12 497 PMID: 27159577
Cotto-Rios and Gavathiotis (2016) Chemical genetics: Unraveling cell death mysteries. Nat.Chem.Biol. 12 470 PMID: 27315536
If you know of a relevant reference for FIN 56, please let us know.
View Related Products by Product Action
Keywords: FIN 56, FIN 56 supplier, FIN56, glutathione, peroxidase, 4, GPX4, activates, ferroptosis, activators, squalene, synthase, acetyl-CoA, carboxylase, ACC, Ferroptosis, Enzyme, Substrates, /, Activators, 6280, Tocris Bioscience
1 Citation for FIN 56
Citations are publications that use Tocris products. Selected citations for FIN 56 include:
Jeff et al (2020) Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis. Elife 9 PMID: 32686647
Do you know of a great paper that uses FIN 56 from Tocris? Please let us know.
Reviews for FIN 56
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.