FGIN-1-27

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Cat.No. 0658 - FGIN-1-27 | C28H37FN2O | CAS No. 142720-24-9
Description: Potent, specific ligand for mitochondrial DBI receptor
Chemical Name: N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Binds specifically and with high affinity to the peptide DBI receptor (benzodiazepine receptor) on mitochondrial membranes, inducing production of neurosteroids, which modulate GABA receptors (EC50 = 3 nM for increase in production of pregnenolone in glial cells). Thus it reduces anxiety without causing sedation.

Compound Libraries

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Technical Data

M. Wt 436.61
Formula C28H37FN2O
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 142720-24-9
PubChem ID 132496
InChI Key VUWXAQFLTSBUDB-UHFFFAOYSA-N
Smiles O=C(N(CCCCCC)CCCCCC)CC2=C(C3=CC=C(F)C=C3)NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.66 100

Preparing Stock Solutions

The following data is based on the product molecular weight 436.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.45 mL 22.9 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References

References are publications that support the biological activity of the product.

Romeo et al (1992) 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR). J.Pharmacol.Exp.Ther. 262 971 PMID: 1326631

Kozikowski et al (1992) Synthesis of (2-arylindol-3-yl)acetamides as probes for mitochondrial steroidogenesis - a new mechanism of GABAA receptor modulation. Angew.Chem.Int.Ed. 31 1060


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Keywords: FGIN-1-27, FGIN-1-27 supplier, Potent, specific, ligand, mitochondrial, DBI, receptor, GABAA, Receptors, FGIN127, Translocator, Protein, 0658, Tocris Bioscience

1 Citation for FGIN-1-27

Citations are publications that use Tocris products. Selected citations for FGIN-1-27 include:

Sutter et al (2003) Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway. Glia 89 564 PMID: 12888831


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