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Biological Activity for FGIN-1-27
Binds specifically and with high affinity to the peptide DBI receptor (benzodiazepine receptor) on mitochondrial membranes, inducing production of neurosteroids, which modulate GABA receptors (EC50 = 3 nM for increase in production of pregnenolone in glial cells). Thus it reduces anxiety without causing sedation.
Technical Data for FGIN-1-27
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FGIN-1-27
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for FGIN-1-27
The following data is based on the product molecular weight 436.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.29 mL||11.45 mL||22.9 mL|
|5 mM||0.46 mL||2.29 mL||4.58 mL|
|10 mM||0.23 mL||1.15 mL||2.29 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References for FGIN-1-27
References are publications that support the biological activity of the product.
Romeo et al (1992) 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR). J.Pharmacol.Exp.Ther. 262 971 PMID: 1326631
Kozikowski et al (1992) Synthesis of (2-arylindol-3-yl)acetamides as probes for mitochondrial steroidogenesis - a new mechanism of GABAA receptor modulation. Angew.Chem.Int.Ed. 31 1060
If you know of a relevant reference for FGIN-1-27, please let us know.
Keywords: FGIN-1-27, FGIN-1-27 supplier, Potent, specific, ligand, mitochondrial, DBI, receptor, GABAA, Receptors, FGIN127, Translocator, Protein, 0658, Tocris Bioscience
1 Citation for FGIN-1-27
Citations are publications that use Tocris products. Selected citations for FGIN-1-27 include:
Sutter et al (2003) Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway. Glia 89 564 PMID: 12888831
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Literature in this Area
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