exo-IWR 1

Discontinued Product

exo-IWR 1 (Cat. No. 3947) has been withdrawn from sale for commercial reasons.
Description: Negative control for endo-IWR 1 (Cat. No. 3532)
Chemical Name: 4-[(3aR,4R,7S,7aS-rel)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Purity: ≥99% (HPLC)
Pathways (1)

Biological Activity for exo-IWR 1

exo-IWR 1 is a negative control for endo-IWR 1 25-fold less active than endo-IWR 1; exhibits decreased activity against the Wnt/β-catenin pathway.

Active Analog also available.

Technical Data for exo-IWR 1

M. Wt 409.44
Formula C25H19N3O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1127442-87-8
PubChem ID 1163034
Smiles O=C(NC5=CC=CC6=C5N=CC=C6)C(C=C4)=CC=C4N2C([C@@]1([H])[C@@H](C3)C=C[C@@H]3[C@]([H])1C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for exo-IWR 1

References are publications that support the biological activity of the product.

Lu et al (2009) Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg.Med.Chem.Lett. 19 3825 PMID: 19410457

Chen et al (2008) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chem.Biol. 5 100

View Related Products by Target

Keywords: exo-IWR 1, exo-IWR 1 supplier, endo-IWR, 1, endo-IWR1, negative, controls, Wnt, beta-catenin, b-catenin, β-catenin, Beta-catenin, 3947, Tocris Bioscience

Citations for exo-IWR 1

Citations are publications that use Tocris products.

Currently there are no citations for exo-IWR 1.

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Pathways for exo-IWR 1

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.