Ercalcitriol

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Cat.No. 3970 - Ercalcitriol | C28H44O3 | CAS No. 60133-18-8
Description: Active metabolite of vitamin D2
Alternative Names: 1α,25-Dihydroxyvitamin D2
Chemical Name: (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7α-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Active metabolite of vitamin D2. Exhibits equipotent antirachitic activity in rats as calcitriol (Cat. No. 2551).

Technical Data

M. Wt 428.65
Formula C28H44O3
Storage Desiccate at -20°C
Purity ≥95% (HPLC)
CAS Number 60133-18-8
PubChem ID 9547243
InChI Key ZGLHBRQAEXKACO-XJRQOBMKSA-N
Smiles C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](/C=C/[C@H](C)C(C)(O)C)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 2.14 5

Preparing Stock Solutions

The following data is based on the product molecular weight 428.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.66 mL 23.33 mL
5 mM 0.47 mL 2.33 mL 4.67 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Rambeck et al (1984) Biological activity of 1 alpha,25-dihydroxyergocalciferol in rachitic chicks and in rats. Int.J.Vitamin.Nutr.Res. 54 135


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Keywords: Ercalcitriol, Ercalcitriol supplier, Vitamin, D, receptor, VDR, agonists, Receptors, VDR-like, 1a,25-DihydroxyvitaminD2, 1alpha,25-DihydroxyvitaminD2, 1α,25-DihydroxyvitaminD2, 1a,25-Dihydroxyvitamin, D2, 3970, Tocris Bioscience

1 Citation for Ercalcitriol

Citations are publications that use Tocris products. Selected citations for Ercalcitriol include:

Kim et al (2014) Vitamin D Inhibits Expression and Activity of Matrix Metalloproteinase in Human Lung Fibroblasts (HFL-1) Cells. Sci Rep 77 73 PMID: 25237378


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Literature in this Area

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