Ercalcitriol

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Cat.No. 3970 - Ercalcitriol | C28H44O3 | CAS No. 60133-18-8
Description: Active metabolite of vitamin D2
Alternative Names: 1α,25-Dihydroxyvitamin D2
Chemical Name: (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7α-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Active metabolite of vitamin D2. Exhibits equipotent antirachitic activity in rats as calcitriol (Cat. No. 2551).

Technical Data

M. Wt 428.65
Formula C28H44O3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 60133-18-8
PubChem ID 9547243
InChI Key ZGLHBRQAEXKACO-XJRQOBMKSA-N
Smiles C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](/C=C/[C@H](C)C(C)(O)C)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 2.14 5

Preparing Stock Solutions

The following data is based on the product molecular weight 428.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.66 mL 23.33 mL
5 mM 0.47 mL 2.33 mL 4.67 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rambeck et al (1984) Biological activity of 1 alpha,25-dihydroxyergocalciferol in rachitic chicks and in rats. Int.J.Vitamin.Nutr.Res. 54 135 PMID:


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Keywords: Vitamin D receptor VDR agonists Receptors VDR-like 1a,25-DihydroxyvitaminD2 1alpha,25-DihydroxyvitaminD2 1α,25-DihydroxyvitaminD2 1a,25-Dihydroxyvitamin D2 Vitamin D Receptors

1 Citation for Ercalcitriol

Citations are publications that use Tocris products. Selected citations for Ercalcitriol include:

Kim et al (2014) Vitamin D Inhibits Expression and Activity of Matrix Metalloproteinase in Human Lung Fibroblasts (HFL-1) Cells. Sci Rep 77 73 PMID: 25237378


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