ER 50891

Pricing Availability   Qty
Description: Selective RARα antagonist
Chemical Name: 4-[5-[8-(1-Methylethyl)-4-phenyl-2-quinolinyl]-1H-pyrrolo-2-benzoic acid
Purity: ≥99% (HPLC)
Citations (5)
Literature (3)

Biological Activity for ER 50891

ER 50891 is an antagonist of RARα receptors (IC50 = 31.2 nM). Displays selective affinity for RARα (relative IC50 values are 1.8, 432 and 535 nM for RARα, RARγ and RARβ respectively).

Compound Libraries for ER 50891

ER 50891 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ER 50891

M. Wt 432.51
Formula C29H24N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 187400-85-7
PubChem ID 10094345
Smiles CC(C)C1=C2C(C(C3=CC=CC=C3)=CC(C4=CC=C(C5=CC=C(C(O)=O)C=C5)N4)=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ER 50891

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.25 100

Preparing Stock Solutions for ER 50891

The following data is based on the product molecular weight 432.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.56 mL 23.12 mL
5 mM 0.46 mL 2.31 mL 4.62 mL
10 mM 0.23 mL 1.16 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for ER 50891

References are publications that support the biological activity of the product.

Kikuchi et al (2001) Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α antagonists. Bioorg.Med.Chem.Lett. 11 1215 PMID: 11354380

Ren et al (2005) Impaired retinoic acid (RA) signal leads to RARβ2 epigenetic silencing and RA resistance. Mol.Cell.Biol. 25 10591 PMID: 16287870

Somenzi et al (2007) Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid. PLoS ONE 9 e836 PMID: 17786207

If you know of a relevant reference for ER 50891, please let us know.

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Keywords: ER 50891, ER 50891 supplier, ER50891, raralpha, rara, rarα, receptors, antagonists, retinoids, retinoic, acid, selective, Retinoic, Acid, Receptors, 3823, Tocris Bioscience

5 Citations for ER 50891

Citations are publications that use Tocris products. Selected citations for ER 50891 include:

Li et al (2017) Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme. Nat Commun 8 ncomms14139 PMID: 28106042

Müller et al (2015) Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines. PLoS One 10 e0131467 PMID: 26173116

Wang et al (2017) Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation. J Mol Cell Biol 9 338 PMID: 28992291

Bi et al (2018) All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity. Cell Biosci 8 48 PMID: 30159139

Do you know of a great paper that uses ER 50891 from Tocris? Please let us know.

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Literature in this Area

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