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Cat.No. 4725 - Eptifibatide | Mpa-Har-Gly-Asp-Trp-Pro-Cys-NH2 | CAS No. 188627-80-7
Description: Glycoprotein IIb/IIIa inhibitor; inhibits platelet aggregation

Biological Activity

Glycoprotein (GP) IIb/IIIa inhibitor. Reversibly and competitively binds to GPIIa/IIIb on platelets, inhibiting aggregation.

Technical Data

M. Wt 832.5
Formula C35H49N11O9S2
Sequence XXGDWPC-NH2

(Modifications: X1 = Mpa, X2 = Har, Disulfide bridge: 1-7, Cys-7 = C-terminal amide)

Storage Store at -20°C
CAS Number 188627-80-7
PubChem ID 448812
Smiles NC(=N)NCCCC[C@@H]1NC(=O)CCSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc3ccccc23)NC(=O)[C@H](CC(O)=O)NC(=O)CNC1=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 5 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 832.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.2 mL 6.01 mL 12.01 mL
5 mM 0.24 mL 1.2 mL 2.4 mL
10 mM 0.12 mL 0.6 mL 1.2 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

O'Shea and Tcheng (2002) Eptifibatide: a potent inhibitor of the platelet receptor integrin glycoprotein IIb/IIIa. Expert Opin.Pharmacother. 3 1199 PMID: 12150697

If you know of a relevant reference for Eptifibatide, please let us know.

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Keywords: Eptifibatide, supplier, Glycoprotein, GP, IIb/IIIa, inhibitors, inhibits, platelets, aggregation, antiplatelet, Integrins, Cell, Adhesion, Molecules, Integrins, Tocris Bioscience

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