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Discontinued ProductEltoprazine hydrochloride (Cat. No. 1860) has been withdrawn from sale for commercial reasons.
5-HT1 and 5-HT2C receptor partial agonist (Ki values are 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively). Reduces 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Gommans et al (1997) Discriminative stimulus properties of eltoprazine. Life Sci. 61 11 PMID: 9200664
Miczek et al (1989) Brain 5-HT and inhibition of aggressive behavior in animals: 5-HIAA and receptor subtypes. Psychopharmacol.Bull. 25 399 PMID: 2483273
Schipper et al (1990) Neurochemical profile of eltoprazine. Drug Metabol.Drug Interact. 8 85 PMID: 1982626
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Keywords: Eltoprazine hydrochloride, Eltoprazine hydrochloride supplier, 5-HT2C, receptor, partial, agonists, 5-HT1, Serotonin, Receptors, 5-HT1B, 1860, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.