Eltoprazine hydrochloride

Discontinued Product

Eltoprazine hydrochloride (Cat. No. 1860) has been withdrawn from sale for commercial reasons.
Description: 5-HT1 and 5-HT2C partial agonist
Chemical Name: 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-piperazine hydrochloride
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Eltoprazine hydrochloride

5-HT1 and 5-HT2C receptor partial agonist (Ki values are 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively). Reduces 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo.

Technical Data for Eltoprazine hydrochloride

M. Wt 256.73
Formula C12H16N2O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 98206-09-8
PubChem ID 3025067
Smiles Cl.C1CN(CCN1)C1=C2OCCOC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Eltoprazine hydrochloride

References for Eltoprazine hydrochloride

References are publications that support the biological activity of the product.

Gommans et al (1997) Discriminative stimulus properties of eltoprazine. Life Sci. 61 11 PMID: 9200664

Miczek et al (1989) Brain 5-HT and inhibition of aggressive behavior in animals: 5-HIAA and receptor subtypes. Psychopharmacol.Bull. 25 399 PMID: 2483273

Schipper et al (1990) Neurochemical profile of eltoprazine. Drug Metabol.Drug Interact. 8 85 PMID: 1982626

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Citations for Eltoprazine hydrochloride

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Currently there are no citations for Eltoprazine hydrochloride.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.