Eltoprazine hydrochloride

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Cat.No. 1860 - Eltoprazine hydrochloride | C12H16N2O2.HCl | CAS No. 98206-09-8
Description: 5-HT1 receptor agonist/partial agonist
Chemical Name: 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-piperazine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

5-HT1 and 5-HT2C receptor partial agonist (Ki values are 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively). Reduces 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo.

Technical Data

M. Wt 256.73
Formula C12H16N2O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 98206-09-8
PubChem ID 3025067
InChI Key JFSOSUNPIXJCIX-UHFFFAOYSA-N
Smiles Cl.C1CN(CCN1)C1=C2OCCOC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25.67 100
phosphate buffered saline 25.67 100

Preparing Stock Solutions

The following data is based on the product molecular weight 256.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.9 mL 19.48 mL 38.95 mL
5 mM 0.78 mL 3.9 mL 7.79 mL
10 mM 0.39 mL 1.95 mL 3.9 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gommans et al (1997) Discriminative stimulus properties of eltoprazine. Life Sci. 61 11 PMID: 9200664

Miczek et al (1989) Brain 5-HT and inhibition of aggressive behavior in animals: 5-HIAA and receptor subtypes. Psychopharmacol.Bull. 25 399 PMID: 2483273

Schipper et al (1990) Neurochemical profile of eltoprazine. Drug Metabol.Drug Interact. 8 85 PMID: 1982626


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Citations for Eltoprazine hydrochloride

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