Ellagic acid

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Cat.No. 3058 - Ellagic acid | C14H6O8 | CAS No. 476-66-4
Description: Selective inhibitor of CK2. Also inhibits glutathione S-transferase
Chemical Name: 2,3,7,8-Tetrahydroxy-[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective, ATP-competitive inhibitor of casein kinase 2 (CK2) (IC50 values are 40, 2900, 3500, 4300 and 9400 nM for CK2, Lyn, PKA, Syk  and FGR respectively). Exhibits antioxidant, antitumor and anticarcinogenic activity and also inhibits glutathione S-transferase.

Technical Data

M. Wt 302.19
Formula C14H6O8
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 476-66-4
PubChem ID 5281855
InChI Key AFSDNFLWKVMVRB-UHFFFAOYSA-N
Smiles OC1=C(O)C=C(C(C3=C2C=C(O)C(O)=C3O4)=C1OC2=O)C4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 0.2 0.65

Preparing Stock Solutions

The following data is based on the product molecular weight 302.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.55 mL 33.09 mL
5 mM 0.66 mL 3.31 mL 6.62 mL
10 mM 0.33 mL 1.65 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cozza et al (2006) Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. J.Med.Chem. 49 2363 PMID: 16610779

Han et al (2006) Antioxidant and apoptosis-inducing activities of ellagic acid. Anticancer Res. 26 3601 PMID: 17094489

Hayeshi et al (2007) The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin. Food Chem.Toxicol. 45 286 PMID: 17046132


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Keywords: Ellagic acid, supplier, Selective, CK2, inhibits, inhibitors, glutathione, S-transferase, Casein, Kinase, 2, Transferases, Casein, Kinase, 2, Tocris Bioscience

Citations for Ellagic acid

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Pathways for Ellagic acid

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