Eletriptan hydrobromide

Pricing Availability Delivery Time Qty
Cat.No. 3862 - Eletriptan hydrobromide | C22H26N2O2S.HBr | CAS No. 177834-92-3
Description: Orally active, selective 5-HT1B/1D agonist
Chemical Name: 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole hydrobromide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Orally active, selective 5-HT1B/1D receptor agonist. Produces a dose-dependent reduction in carotid artery blood flow in vivo. Displays antimigraine activity.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Eletriptan hydrobromide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 463.43
Formula C22H26N2O2S.HBr
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 177834-92-3
PubChem ID 656631
InChI Key UTINOWOSWSPFLJ-FSRHSHDFSA-N
Smiles CN1[C@@H](CC3=CNC2=CC=C(CCS(=O)(C4=CC=CC=C4)=O)C=C23)CCC1.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 463.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.58 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Napier et al (1999) Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]-eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur.J.Pharmacol. 368 259 PMID: 10193663

Gupta et al (2000) The in vivo pharmacological profile of eletriptan (UK-116,044): a potent and novel 5-HT(1B/1D) receptor agonist. Eur.J.Pharmacol. 398 73 PMID: 10856450

Willems et al (1998) Porcine carotid vascular effects of eletriptan (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity. Naunyn-Schmied.Arch.Pharmacol. 358 212 PMID:


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Citations for Eletriptan hydrobromide

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