Eletriptan hydrobromide

Discontinued Product

Eletriptan hydrobromide (Cat. No. 3862) has been withdrawn from sale for commercial reasons.
Description: 5-HT1B and 5-HT1D agonist; orally active
Chemical Name: 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole hydrobromide
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for Eletriptan hydrobromide

Orally active, selective 5-HT1B/1D receptor agonist. Produces a dose-dependent reduction in carotid artery blood flow in vivo. Displays antimigraine activity.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Eletriptan hydrobromide

Eletriptan hydrobromide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Eletriptan hydrobromide

M. Wt 463.43
Formula C22H26N2O2S.HBr
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 177834-92-3
PubChem ID 656631
Smiles CN1[C@@H](CC3=CNC2=CC=C(CCS(=O)(C4=CC=CC=C4)=O)C=C23)CCC1.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Eletriptan hydrobromide

References for Eletriptan hydrobromide

References are publications that support the biological activity of the product.

Napier et al (1999) Characterisation of the 5-HT receptor binding profile of eletr. and kinetics of [3H]-eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur.J.Pharmacol. 368 259 PMID: 10193663

Gupta et al (2000) The in vivo pharmacological profile of eletr. (UK-116,044): a potent and novel 5-HT(1B/1D) receptor agonist. Eur.J.Pharmacol. 398 73 PMID: 10856450

Willems et al (1998) Porcine carotid vascular effects of eletr. (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity. Naunyn-Schmied.Arch.Pharmacol. 358 212

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Keywords: Eletriptan hydrobromide, Eletriptan hydrobromide supplier, 5-HT1B, 5-HT1D, 5-HT1B/1D, selective, orally, active, agonists, receptors, serotonin, Pfizer, Receptors, 3862, Tocris Bioscience

Citations for Eletriptan hydrobromide

Citations are publications that use Tocris products.

Currently there are no citations for Eletriptan hydrobromide.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.