Eletriptan hydrobromide

Pricing Availability   Qty
Cat.No. 3862 - Eletriptan hydrobromide | C22H26N2O2S.HBr | CAS No. 177834-92-3
Description: 5-HT1B and 5-HT1D agonist; orally active
Chemical Name: 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole hydrobromide
Purity: ≥99% (HPLC)
Literature (4)

Biological Activity

Orally active, selective 5-HT1B/1D receptor agonist. Produces a dose-dependent reduction in carotid artery blood flow in vivo. Displays antimigraine activity.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Eletriptan hydrobromide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 463.43
Formula C22H26N2O2S.HBr
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 177834-92-3
PubChem ID 656631
Smiles CN1[C@@H](CC3=CNC2=CC=C(CCS(=O)(C4=CC=CC=C4)=O)C=C23)CCC1.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 463.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.58 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.


References are publications that support the biological activity of the product.

Napier et al (1999) Characterisation of the 5-HT receptor binding profile of eletr. and kinetics of [3H]-eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur.J.Pharmacol. 368 259 PMID: 10193663

Gupta et al (2000) The in vivo pharmacological profile of eletr. (UK-116,044): a potent and novel 5-HT(1B/1D) receptor agonist. Eur.J.Pharmacol. 398 73 PMID: 10856450

Willems et al (1998) Porcine carotid vascular effects of eletr. (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity. Naunyn-Schmied.Arch.Pharmacol. 358 212

If you know of a relevant reference for Eletriptan hydrobromide, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT1B Receptor Agonists

Keywords: Eletriptan hydrobromide, Eletriptan hydrobromide supplier, 5-HT1B, 5-HT1D, 5-HT1B/1D, selective, orally, active, agonists, receptors, serotonin, Pfizer, Receptors, 3862, Tocris Bioscience

Citations for Eletriptan hydrobromide

Citations are publications that use Tocris products.

Currently there are no citations for Eletriptan hydrobromide. Do you know of a great paper that uses Eletriptan hydrobromide from Tocris? Please let us know.

Reviews for Eletriptan hydrobromide

There are currently no reviews for this product. Be the first to review Eletriptan hydrobromide and earn rewards!

Have you used Eletriptan hydrobromide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.


Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.


Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.