Endogenous polyunsaturated fatty acid. Stimulates ERK1/2 and C/EBPβ phosphorylation, and induces demethylation of CpG island B in U937 leukemia cells. Attenuates proliferation of U9137 cells, and induces cell cycle arrest and apoptosis in pancreatic cells in vitro. Also inhibits leukotriene B4 synthesis in rats.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 302.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.31 mL||16.53 mL||33.06 mL|
|5 mM||0.66 mL||3.31 mL||6.61 mL|
|10 mM||0.33 mL||1.65 mL||3.31 mL|
|50 mM||0.07 mL||0.33 mL||0.66 mL|
References are publications that support the products' biological activity.
Ceccarelli et al (2014) Eicosapentaenoic acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. PLoS One 9 e85025 PMID: 24454781
James et al (1993) Effect of dietary supplementation with n-9 eicosatrienoic acid on leukotriene B4 synthesis in rats: a novel approach to inhibition of eicosanoid synthesis. J.Exp.Med. 178 2261 PMID: 8245797
Lai et al (1996) Cell cycle arrest and induction of apoptosis in pancreatic cancer cells exposed to eicosapentaenoic acid in vitro. Br.J.Cancer 74 1375 PMID: 8912532
If you know of a relevant reference for Eicosapentaenoic Acid, please let us know.
Keywords: Eicosapentaenoic Acid, supplier, endogenous, polyunsaturated, fatty, acids, stimulates, ERK, phosphorylation, leukotriene-B4, synthesis, inhibits, ERK, Leukotriene, and, Related, Receptors, ERK, Tocris Bioscience
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Literature in this Area
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MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.