DV 7028 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 4480 - DV 7028 hydrochloride | C21H25FN4O3.HCl | CAS No. 133364-62-2
Description: Selective 5-HT2A antagonist; antithrombotic
Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2H-pyrido[1,2-a]-1,3,5-triazine-2,4(3H)-dione hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective 5-HT2A receptor antagonist (Ki = 22 nM for at 5-HT2 receptors). Exhibits no affinity for 5-HT1A, 5-HT1B or 5-HT1D receptors. Inhibits collagen-induced serotonin secretion and platelet aggregation; displays no effect on serotonin uptake by platelets. Shown to inhibit arterial thrombus formation, but not venous thrombosis, in rat models.

Technical Data

M. Wt 436.91
Formula C21H25FN4O3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 133364-62-2
PubChem ID 19746041
InChI Key MEULLZRAYZSDGF-UHFFFAOYSA-N
Smiles O=C(C4=CC=C(F)C=C4)C(CC3)CCN3CCN2C(N1CCCCC1=NC2=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.37 10mM with gentle warming
water 4.37 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 436.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.44 mL 22.89 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.14 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Pawlak et al (1998) A potent 5-hydroxytryptamine receptor (5-HT2A) antagonist, DV-7028, delays arterial thrombosis development in rats. Thromb.Res. 90 259 PMID: 9700856

Shibano et al (1992) Pharmacological profile of a new 5-hydroxytryptamine 2 receptor antagonist, DV-7028. Arch.Int.Pharmacodyn.Ther. 319 114 PMID: 1285670


If you know of a relevant reference for DV 7028 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT2A Receptor Antagonists

Keywords: DV7028 hydrochloride antithrombotics serotonergics 5-HT2A selective antagonists arterial thrombus formation 5-HT2A Receptors

Citations for DV 7028 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for DV 7028 hydrochloride. Do you know of a great paper that uses DV 7028 hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for DV 7028 hydrochloride

Protocols

TODO: Add Protocols