DuP 697

Pricing Availability Delivery Time Qty
Cat.No. 1430 - DuP 697 | C17H12BrFO2S2 | CAS No. 88149-94-4
Description: Cyclooxygenase-2 (COX-2) inhibitor
Chemical Name: 5-Bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-thiophene
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Potent and selective inhibitor of cyclooxygenase-2 (IC50 values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo. Orally active.

Compound Libraries

DuP 697 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 411.3
Formula C17H12BrFO2S2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 88149-94-4
PubChem ID 3177
InChI Key AJFTZWGGHJXZOB-UHFFFAOYSA-N
Smiles CS(=O)(=O)C1=CC=C(C=C1)C1=C(SC(Br)=C1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 411.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.16 mL 24.31 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
10 mM 0.24 mL 1.22 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gans et al (1990) Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor. J.Pharmacol.Exp.Ther. 254 180 PMID: 2366180

Gierse et al (1995) Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem.J. 305 479 PMID: 7832763

Rossoni et al (2002) Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit. Br.J.Pharmacol. 135 1540 PMID: 11906968


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Keywords: DuP 697, supplier, Cyclooxygenase-2, COX-2, inhibitors, inhibits, Cyclooxygenase, Oxygenases, Oxidases, DuP697, Cyclooxygenase, Tocris Bioscience

3 Citations for DuP 697

Citations are publications that use Tocris products. Selected citations for DuP 697 include:

Gonnermann et al (2015) Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity. Oncoimmunology 4 e988460 PMID: 25949900

Passafaro et al (2011) Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland. Neuroscience 8 138 PMID: 22013477

Wong et al (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res 104 228 PMID: 19096033


Do you know of a great paper that uses DuP 697 from Tocris? If so please let us know.

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