Donitriptan hydrochloride

Discontinued Product

Donitriptan hydrochloride (Cat. No. 3665) has been withdrawn from sale for commercial reasons.
Description: 5-HT1B/1D agonist
Chemical Name: 1-[[[3-(2-Aminoethyl)-1H-indol-5-yl]oxy]acetyl]-4-(4-cyanophenyl)-piperazine hydrochloride
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Donitriptan hydrochloride

Brain penetrant 5-HT1B/1D agonist (pKi values are 9.3 and 9.4 for 5-HT1D and 5-HT1B respectively). Inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Displays antimigraine activity.

Technical Data for Donitriptan hydrochloride

M. Wt 439.94
Formula C23H25N5O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 170911-68-9
PubChem ID 197705
Smiles NCCC2=CNC1=CC=C(OCC(N3CCN(C4=CC=C(C#N)C=C4)CC3)=O)C=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Donitriptan hydrochloride

References for Donitriptan hydrochloride

References are publications that support the biological activity of the product.

Letienne et al (2003) Donitriptan selectively decreases jugular venous oxygen saturation in the anesthetized pig: further insights into its mechanism of action relevant to headache relief. J.Pharmacol.Exp.Ther. 305 749 PMID: 12606602

Letienne et al (2005) Donitriptan decreases jugular venous oxygen saturation in rats in the absence of cranial vasoconstriction: an overlooked mechanism of antimigraine action? J.Pharmacol.Exp.Ther. 315 849 PMID: 16027226

Munoz-Islas et al (2006) Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilation via 5-HT1B rather than 5-HT1D receptors. Br.J.Pharmacol. 149 82 PMID: 16880765

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Keywords: Donitriptan hydrochloride, Donitriptan hydrochloride supplier, serotonin, 5-HT1B, 5-HT1D, 5-HT1B/1D, receptors, agonists, Receptors, 3665, Tocris Bioscience

Citations for Donitriptan hydrochloride

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Currently there are no citations for Donitriptan hydrochloride.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.