Endogenous σ1 receptor ligand and psychoactive plant compound (Ki = 14.8 μM). Binding to σ1 inhibits voltage-gated Na+ channels and is responsible for the behavioral effects of DMT. Also a 5-HT2A receptor agonist and inhibitor of 5-HT uptake at plasma membrane serotonin transporters (SERT) (Ki = 4.0 μM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 188.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.31 mL||26.56 mL||53.12 mL|
|5 mM||1.06 mL||5.31 mL||10.62 mL|
|10 mM||0.53 mL||2.66 mL||5.31 mL|
|50 mM||0.11 mL||0.53 mL||1.06 mL|
References are publications that support the products' biological activity.
Fontanilla et al (2009) The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science 323 934 PMID: 19213917
Cozzi et al (2009) Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transportere and the vesicle monoamine transporter. J.Neural Transm. 116 1591 PMID: 19756361
If you know of a relevant reference for DMT, please let us know.
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Keywords: DMT, supplier, sigma, σ, sigma1, σ1, receptors, ligands, 5-HT2A, serotonin, agonists, SERT, transporters, 5-HT, N,N-Dimethyltryptamine, Sigma1, Receptors, 5-HT, Transporters, 5-HT2A, Receptors, Sigma1, Receptors, Tocris Bioscience
1 Citation for DMT
Citations are publications that use Tocris products. Selected citations for DMT include:
Do-Monte et al (2015) A temporal shift in the circuits mediating retrieval of fear memory. BMC Cancer 519 460 PMID: 25600268
Do you know of a great paper that uses DMT from Tocris? If so please let us know.
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