DMT

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Cat.No. 3428 - DMT | C12H16N2 | CAS No. 61-50-7
Description: Endogenous σ1 ligand. Also 5-HT2A agonist
Alternative Names: Dimethyltryptamine
Chemical Name: N,N-Dimethyl-1H-indole-3-ethanamine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Endogenous σ1 receptor ligand and psychoactive plant compound (Ki = 14.8 μM). Binding to σ1 inhibits voltage-gated Na+ channels and is responsible for the behavioral effects of DMT. Also a 5-HT2A receptor agonist and inhibitor of 5-HT uptake at plasma membrane serotonin transporters (SERT) (Ki = 4.0 μM).

Technical Data

M. Wt 188.27
Formula C12H16N2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 61-50-7
PubChem ID 6089
InChI Key DMULVCHRPCFFGV-UHFFFAOYSA-N
Smiles CN(CCC2=CNC1=CC=CC=C12)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 0.94 5

Preparing Stock Solutions

The following data is based on the product molecular weight 188.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.31 mL 26.56 mL 53.12 mL
5 mM 1.06 mL 5.31 mL 10.62 mL
10 mM 0.53 mL 2.66 mL 5.31 mL
50 mM 0.11 mL 0.53 mL 1.06 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Fontanilla et al (2009) The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science 323 934 PMID: 19213917

Cozzi et al (2009) Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transportere and the vesicle monoamine transporter. J.Neural Transm. 116 1591 PMID: 19756361


If you know of a relevant reference for DMT, please let us know.

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View all σ1 Receptor Ligands

Keywords: DMT, supplier, sigma, σ, sigma1, σ1, receptors, ligands, 5-HT2A, serotonin, agonists, SERT, transporters, 5-HT, N,N-Dimethyltryptamine, Sigma1, Receptors, 5-HT, Transporters, 5-HT2A, Receptors, Sigma1, Receptors, Tocris Bioscience

1 Citation for DMT

Citations are publications that use Tocris products. Selected citations for DMT include:

Do-Monte et al (2015) A temporal shift in the circuits mediating retrieval of fear memory. BMC Cancer 519 460 PMID: 25600268


Do you know of a great paper that uses DMT from Tocris? If so please let us know.

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Literature in this Area

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