DMT

Discontinued Product

DMT (Cat. No. 3428) has been withdrawn from sale for commercial reasons.
Cat.No. 3428 - DMT | C12H16N2 | CAS No. 61-50-7
Description: Endogenous σ1 ligand. Also 5-HT2A agonist
Alternative Names: Dimethyltryptamine
Chemical Name: N,N-Dimethyl-1H-indole-3-ethanamine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature

Biological Activity

Endogenous σ1 receptor ligand and psychoactive plant compound (Ki = 14.8 μM). Binding to σ1 inhibits voltage-gated Na+ channels and is responsible for the behavioral effects of DMT. Also a 5-HT2A receptor agonist and inhibitor of 5-HT uptake at plasma membrane serotonin transporters (SERT) (Ki = 4.0 μM).

Technical Data

M. Wt 188.27
Formula C12H16N2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 61-50-7
PubChem ID 6089
InChI Key DMULVCHRPCFFGV-UHFFFAOYSA-N
Smiles CN(CCC2=CNC1=CC=CC=C12)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Fontanilla et al (2009) The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science 323 934 PMID: 19213917

Cozzi et al (2009) Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transportere and the vesicle monoamine transporter. J.Neural Transm. 116 1591 PMID: 19756361

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Keywords: DMT, DMT supplier, sigma, σ, sigma1, σ1, receptors, ligands, 5-HT2A, serotonin, agonists, SERT, transporters, 5-HT, N,N-Dimethyltryptamine, Sigma1, Receptors, Transporters, 3428, Tocris Bioscience

1 Citation for DMT

Citations are publications that use Tocris products. Selected citations for DMT include:

Do-Monte et al (2015) A temporal shift in the circuits mediating retrieval of fear memory. BMC Cancer 519 460 PMID: 25600268


Reviews for DMT

Average Rating: 5 (Based on 1 Review.)

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DMT protects sigma-1 receptor against photolabeling by iodoazidofenpropimorph
By Anonymous on 02/26/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: mouse spinal cord homogenate

Photolabeling experiment on mouse spinal cord homogenate

review image

Literature in this Area

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New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

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