Pricing Availability Delivery Time Qty
Cat.No. 3428 - DMT | C12H16N2 | CAS No. 61-50-7
Description: Endogenous σ1 ligand. Also 5-HT2A agonist
Alternative Names: Dimethyltryptamine
Chemical Name: N,N-Dimethyl-1H-indole-3-ethanamine
Purity: ≥99% (HPLC)
Citations (1)
Reviews (1)

Biological Activity

Endogenous σ1 receptor ligand and psychoactive plant compound (Ki = 14.8 μM). Binding to σ1 inhibits voltage-gated Na+ channels and is responsible for the behavioral effects of DMT. Also a 5-HT2A receptor agonist and inhibitor of 5-HT uptake at plasma membrane serotonin transporters (SERT) (Ki = 4.0 μM).

Technical Data

M. Wt 188.27
Formula C12H16N2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 61-50-7
PubChem ID 6089
Smiles CN(CCC2=CNC1=CC=CC=C12)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 0.94 5

Preparing Stock Solutions

The following data is based on the product molecular weight 188.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.31 mL 26.56 mL 53.12 mL
5 mM 1.06 mL 5.31 mL 10.62 mL
10 mM 0.53 mL 2.66 mL 5.31 mL
50 mM 0.11 mL 0.53 mL 1.06 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Fontanilla et al (2009) The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science 323 934 PMID: 19213917

Cozzi et al (2009) Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transportere and the vesicle monoamine transporter. J.Neural Transm. 116 1591 PMID: 19756361

If you know of a relevant reference for DMT, please let us know.

View Related Products by Product Action

View all σ1 Receptor Ligands

Keywords: DMT, supplier, sigma, σ, sigma1, σ1, receptors, ligands, 5-HT2A, serotonin, agonists, SERT, transporters, 5-HT, N,N-Dimethyltryptamine, Sigma1, Receptors, 5-HT, Transporters, 5-HT2A, Receptors, Sigma1, Receptors, Tocris Bioscience

1 Citation for DMT

Citations are publications that use Tocris products. Selected citations for DMT include:

Do-Monte et al (2015) A temporal shift in the circuits mediating retrieval of fear memory. BMC Cancer 519 460 PMID: 25600268

Do you know of a great paper that uses DMT from Tocris? If so please let us know.

Reviews for DMT

Average Rating: 5 (Based on 1 Review)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used DMT?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Filter by:

DMT protects sigma-1 receptor against photolabeling by iodoazidofenpropimorph
By Anonymous on 02/26/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: mouse spinal cord homogenate

Photolabeling experiment on mouse spinal cord homogenate

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells