DMNB

Pricing Availability Delivery Time Qty
Cat.No. 2088 - DMNB | C9H9NO5 | CAS No. 20357-25-9
Description: DNA-PK inhibitor
Chemical Name: 4,5-Dimethoxy-2-nitrobenzaldehyde
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 15 μM), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.

Technical Data

M. Wt 211.15
Formula C9H9NO5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 20357-25-9
PubChem ID 88505
InChI Key YWSPWKXREVSQCA-UHFFFAOYSA-N
Smiles COC1=C(OC)C=C(C(C=O)=C1)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.11 100
ethanol 5.28 25mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 211.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.74 mL 23.68 mL 47.36 mL
5 mM 0.95 mL 4.74 mL 9.47 mL
10 mM 0.47 mL 2.37 mL 4.74 mL
50 mM 0.09 mL 0.47 mL 0.95 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Durant and Karran (2003) Vanillins - a novel family of DNA-PK inhibitors. Nucleic Acids Res. 31 5501 PMID: 14500812


If you know of a relevant reference for DMNB, please let us know.

View Related Products by Product Action

View all DNA-Dependent Protein Kinase Inhibitors

Keywords: DMNB, supplier, DNA-dependent, protein, kinases, inhibitors, inhibits, Checkpoint, Control, Kinases, DNA-PK, DNA-dependent, Protein, Kinase, Tocris Bioscience

Citations for DMNB

Citations are publications that use Tocris products.

Currently there are no citations for DMNB. Do you know of a great paper that uses DMNB from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for DMNB

Protocols

TODO: Add Protocols