(±)-Nipecotic acid

Discontinued Product

(±)-Nipecotic acid (Cat. No. 0236) has been withdrawn from sale for commercial reasons.
Cat.No. 0236 - (±)-Nipecotic acid | C6H11NO2 | CAS No. 60252-41-7
Description: GABA uptake inhibitor
Chemical Name: (±)-3-Piperidine carboxylic acid
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

GABA uptake inhibitor. IC50 values are 8, 38, 106 and 2370 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.

Technical Data

M. Wt 129.16
Formula C6H11NO2
Storage Store at RT
CAS Number 60252-41-7
PubChem ID 4498
InChI Key XJLSEXAGTJCILF-UHFFFAOYSA-N
Smiles O=C(C1CNCCC1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References

References are publications that support the biological activity of the product.

Borden et al (1994) Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219 PMID: 7851497

Krogsgaard-Larsen et al (1981) GABA agonists, antagonists and uptake inhibitors. Design and therapeutic aspects. J.Med.Chem. 24 1377 PMID: 6118436

Schousboe et al (1979) Effects of GABA analogues of restricted conformation on GABA transport in astrocytes and brain cortex slices and on GABA binding. J.Neurochem. 33 181 PMID: 458448

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Keywords: (±)-Nipecotic acid, (±)-Nipecotic acid supplier, GABA, reuptake, inhibitors, inhibits, BGT-1, GAT-1, GAT-2, GAT-3, GAT-4, Transporters, Monoamine, Neurotransmitter, 0236, Tocris Bioscience

1 Citation for (±)-Nipecotic acid

Citations are publications that use Tocris products. Selected citations for (±)-Nipecotic acid include:

Reali et al (2011) GABAergic signalling in a neurogenic niche of the turtle spinal cord. J Physiol 589 5633 PMID: 21911613


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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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