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Discontinued Product(±)-Nipecotic acid (Cat. No. 0236) has been withdrawn from sale for commercial reasons.
GABA uptake inhibitor. IC50 values are 8, 38, 106 and 2370 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Borden et al (1994) Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219 PMID: 7851497
Krogsgaard-Larsen et al (1981) GABA agonists, antagonists and uptake inhibitors. Design and therapeutic aspects. J.Med.Chem. 24 1377 PMID: 6118436
Schousboe et al (1979) Effects of GABA analogues of restricted conformation on GABA transport in astrocytes and brain cortex slices and on GABA binding. J.Neurochem. 33 181 PMID: 458448
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Keywords: (±)-Nipecotic acid, (±)-Nipecotic acid supplier, GABA, reuptake, inhibitors, inhibits, BGT-1, GAT-1, GAT-2, GAT-3, GAT-4, Transporters, Monoamine, Neurotransmitter, 0236, Tocris Bioscience
1 Citation for (±)-Nipecotic acid
Citations are publications that use Tocris products. Selected citations for (±)-Nipecotic acid include:
Reali et al (2011) GABAergic signalling in a neurogenic niche of the turtle spinal cord. J Physiol 589 5633 PMID: 21911613
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.