(±)-Nipecotic acid

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Cat.No. 0236 - (±)-Nipecotic acid | C6H11NO2 | CAS No. 60252-41-7
Description: GABA uptake inhibitor
Chemical Name: (±)-3-Piperidine carboxylic acid
Datasheet
Citations (1)
Literature

Biological Activity

GABA uptake inhibitor. IC50 values are 8, 38, 106 and 2370 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.

Technical Data

M. Wt 129.16
Formula C6H11NO2
Storage Store at RT
CAS Number 60252-41-7
PubChem ID 4498
InChI Key XJLSEXAGTJCILF-UHFFFAOYSA-N
Smiles O=C(C1CNCCC1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 129.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.74 mL 38.71 mL 77.42 mL
5 mM 1.55 mL 7.74 mL 15.48 mL
10 mM 0.77 mL 3.87 mL 7.74 mL
50 mM 0.15 mL 0.77 mL 1.55 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Borden et al (1994) Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219 PMID: 7851497

Krogsgaard-Larsen et al (1981) GABA agonists, antagonists and uptake inhibitors. Design and therapeutic aspects. J.Med.Chem. 24 1377 PMID: 6118436

Schousboe et al (1979) Effects of GABA analogues of restricted conformation on GABA transport in astrocytes and brain cortex slices and on GABA binding. J.Neurochem. 33 181 PMID: 458448


If you know of a relevant reference for (±)-Nipecotic acid, please let us know.

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Keywords: GABA reuptake inhibitors inhibits BGT-1 GAT-1 GAT-2 GAT-3 GAT-4 Transporters Monoamine Neurotransmitter GABA Transporters

1 Citation for (±)-Nipecotic acid

Citations are publications that use Tocris products. Selected citations for (±)-Nipecotic acid include:

Reali et al (2011) GABAergic signalling in a neurogenic niche of the turtle spinal cord. J Physiol 589 5633 PMID: 21911613


Do you know of a great paper that uses (±)-Nipecotic acid from Tocris? If so please let us know.

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Pathways for (±)-Nipecotic acid

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