GABA uptake inhibitor. IC50 values are 8, 38, 106 and 2370 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 129.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||7.74 mL||38.71 mL||77.42 mL|
|5 mM||1.55 mL||7.74 mL||15.48 mL|
|10 mM||0.77 mL||3.87 mL||7.74 mL|
|50 mM||0.15 mL||0.77 mL||1.55 mL|
References are publications that support the products' biological activity.
Borden et al (1994) Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219 PMID: 7851497
Krogsgaard-Larsen et al (1981) GABA agonists, antagonists and uptake inhibitors. Design and therapeutic aspects. J.Med.Chem. 24 1377 PMID: 6118436
Schousboe et al (1979) Effects of GABA analogues of restricted conformation on GABA transport in astrocytes and brain cortex slices and on GABA binding. J.Neurochem. 33 181 PMID: 458448
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Keywords: (±)-Nipecotic acid, supplier, GABA, reuptake, inhibitors, inhibits, BGT-1, GAT-1, GAT-2, GAT-3, GAT-4, Transporters, Monoamine, Neurotransmitter, GABA, Transporters, GABA, Transporters, Tocris Bioscience
1 Citation for (±)-Nipecotic acid
Citations are publications that use Tocris products. Selected citations for (±)-Nipecotic acid include:
Reali et al (2011) GABAergic signalling in a neurogenic niche of the turtle spinal cord. J Physiol 589 5633 PMID: 21911613
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