Hallucinogenic compound that inhibits 5-HT and dopamine uptake.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 229.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.35 mL||21.77 mL||43.54 mL|
|5 mM||0.87 mL||4.35 mL||8.71 mL|
|10 mM||0.44 mL||2.18 mL||4.35 mL|
|50 mM||0.09 mL||0.44 mL||0.87 mL|
References are publications that support the biological activity of the product.
Iravani et al (2000) Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphe nucleus slices. Synapse 36 275 PMID: 10819905
Fleckenstein et al (2007) New insights into the mechanism of action of amphetamines. Annu.Rev.Pharmacol.Toxicol. 47 681 PMID: 17209801
Boyle et al (2007) MDMA ("ecstasy") suppresses the innate IFN-γ response in vivo: a critical role for the anti-inflammatory cytokine IL-10. Eur.J.Pharmacol. 572 228 PMID: 17689526
If you know of a relevant reference for (±)-MDMA hydrochloride, please let us know.
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Citations for (±)-MDMA hydrochloride
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Reviews for (±)-MDMA hydrochloride
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Rats self-administered MDMA (0.30 mg/kg/infusion, i.v.). We then showed that, following extinction of MDMA seeking, discrete MDMA-associated cues reinstated MDMA-seeking behavior. Also, the magnitude of reinstatement was positively correlated with the level of responding during MDMA self-administration.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.