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Description: Mixed mGlu2 agonist/ mGlu3 antagonist
Chemical Name: (1S,2S,4R,5R,6S)-rel-2-Amino-4-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity
Selective metabotropic glutamate ligand for mGlu2 and mGlu3 receptors (Ki values are 0.165 μM and 0.302 μM respectively). Acts as an agonist at mGlu2 and antagonist at mGlu3. Analog of LY 354740 (Cat. No. 3246).
Technical Data
| M. Wt | 199.21 |
| Formula | C9H13NO4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 852679-66-4 |
| PubChem ID | 11310142 |
| InChI Key | BQVZICWQBFTOJX-QNDZYWSYSA-N |
| Smiles | N[C@]1([C@](O)=O)[C@@]2([H])[C@@]([C@@H]2[C@](O)=O)([H])[C@H](C)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 19.92 | 100 | |
| 1eq. NaOH | 19.92 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 199.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.02 mL | 25.1 mL | 50.2 mL |
| 5 mM | 1 mL | 5.02 mL | 10.04 mL |
| 10 mM | 0.5 mL | 2.51 mL | 5.02 mL |
| 50 mM | 0.1 mL | 0.5 mL | 1 mL |
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References
References are publications that support the biological activity of the product.
Dominguez et al (2005) Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist. J.Med.Chem. 48 3605 PMID: 15887967
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Keywords: (±)-LY 395756, (±)-LY 395756 supplier, LY395756, agonist, metabotropic, glutamate, ligand, receptor, receptors, mGlu2, mGlu3, Glutamate, (Metabotropic), Group, II, Receptors, 3272, Tocris Bioscience
2 Citations for (±)-LY 395756
Citations are publications that use Tocris products. Selected citations for (±)-LY 395756 include:
Johnson (2017) Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and DA release in the dorsal striatum. Neuropharmacology 117 114 PMID: 28159646
Wang et al (2013) Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons. Mol Pain 8 e61787 PMID: 23593498
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