(±)-LY 395756
Biological Activity
Selective metabotropic glutamate ligand for mGlu2 and mGlu3 receptors (Ki values are 0.165 μM and 0.302 μM respectively). Acts as an agonist at mGlu2 and antagonist at mGlu3. Analog of LY 354740 (Cat. No. 3246).
Technical Data
| M. Wt | 199.21 |
| Formula | C9H13NO4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 852679-66-4 |
| PubChem ID | 11310142 |
| InChI Key | BQVZICWQBFTOJX-QNDZYWSYSA-N |
| Smiles | N[C@]1([C@](O)=O)[C@@]2([H])[C@@]([C@@H]2[C@](O)=O)([H])[C@H](C)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 19.92 | 100 | |
| 1eq. NaOH | 19.92 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 199.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.02 mL | 25.1 mL | 50.2 mL |
| 5 mM | 1 mL | 5.02 mL | 10.04 mL |
| 10 mM | 0.5 mL | 2.51 mL | 5.02 mL |
| 50 mM | 0.1 mL | 0.5 mL | 1 mL |
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References
References are publications that support the products' biological activity.
Dominguez et al (2005) Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist. J.Med.Chem. 48 3605 PMID: 15887967
If you know of a relevant reference for (±)-LY 395756, please let us know.
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View all Glutamate (Metabotropic) Group II Receptor Agonists
Keywords: LY395756 agonist metabotropic glutamate ligand receptor receptors mGlu2 mGlu3 Glutamate (Metabotropic) Group II Receptors
1 Citation for (±)-LY 395756
Citations are publications that use Tocris products. Selected citations for (±)-LY 395756 include:
Wang et al (2013) Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons. Mol Pain 8 e61787 PMID: 23593498
Do you know of a great paper that uses (±)-LY 395756 from Tocris? If so please let us know.
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