DL-AP5 Sodium salt

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Cat.No. 3693 - DL-AP5 Sodium salt | C5H11NNaO5P | CAS No. 1303993-72-7
Description: Potent and selective NMDA antagonist; sodium salt of DL-AP5
Chemical Name: DL-2-Amino-5-phosphonopentanoic acid sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Reviews (2)
Literature (11)

Biological Activity for DL-AP5 Sodium salt

DL-AP5 Sodium salt is the sodium salt of DL-AP5 (Cat. No. 0105) and a racemic mixture of the D- and L-isomers of AP5, a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 (Cat. No. 0106) is the more active isomer and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection of D-AP5, NMDA-response is rapidly reduced, with no effect seen on spontaneously active neurons.

DL mixture, D-isomer and L-isomer also available.

Technical Data for DL-AP5 Sodium salt

M. Wt 219.11
Formula C5H11NNaO5P
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1303993-72-7
PubChem ID 52974251
InChI Key KWRCYAPNGUCHOE-UHFFFAOYSA-M
Smiles [Na+].NC(CCCP(O)([O-])=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DL-AP5 Sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 21.91 100

Preparing Stock Solutions for DL-AP5 Sodium salt

The following data is based on the product molecular weight 219.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.56 mL 22.82 mL 45.64 mL
5 mM 0.91 mL 4.56 mL 9.13 mL
10 mM 0.46 mL 2.28 mL 4.56 mL
50 mM 0.09 mL 0.46 mL 0.91 mL

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Product Datasheets for DL-AP5 Sodium salt

Certificate of Analysis / Product Datasheet
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References for DL-AP5 Sodium salt

References are publications that support the biological activity of the product.

Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024

Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378 PMID: 6145492


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Keywords: DL-AP5 Sodium salt, DL-AP5 Sodium salt supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, DLAP5, AP5, NMDA, 3693, Tocris Bioscience

8 Citations for DL-AP5 Sodium salt

Citations are publications that use Tocris products. Selected citations for DL-AP5 Sodium salt include:

Pati et al (2020) Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior ELife 9 PMID: 32955432

Thomsen et al (2016) Fixed single-cell transcriptomic characterization of human radial glial diversity. Sci Rep 13 87 PMID: 26524239

Pan et al (2016) Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice. PLoS One 6 28137 PMID: 27319800

Cazares et al (2016) Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn. J Neurosci 36 11208 PMID: 27807164


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Reviews for DL-AP5 Sodium salt

Average Rating: 5 (Based on 2 Reviews.)

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Works as expected..
By Anonymous on 06/01/2020
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Paraventricular nucleus of hypothalamus

DL-AP5 (40 micromolar) blocked spontaneous excitatory postsynaptic currents in an ex-vivo slice preparation.

PMID: 32133707

NMDA glutamate site antagonist.
By Syed Ali on 01/04/2018
Assay Type: Ex Vivo
Species: Mouse

This small molecule was used as NMDA glutamate site antagonist in ex-vivo patch clamp electrophysiology to investigate neuronal excitability.


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