L-Quisqualic acid

Pricing Availability   Qty
Description: AMPA agonist; also group I mGlu agonist
Chemical Name: (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
Purity: ≥99% (HPLC)
Citations (9)
Literature (4)

Biological Activity for L-Quisqualic acid

L-Quisqualic acid is a glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. L-Quisqualic acid sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect).

Technical Data for L-Quisqualic acid

M. Wt 189.13
Formula C5H7N3O5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 52809-07-1
PubChem ID 40539
Smiles O=C1N(C[C@]([H])(N)C(O)=O)OC(N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-Quisqualic acid

Solvent Max Conc. mg/mL Max Conc. mM
1eq. NaOH 18.91 100
water 1.89 10

Preparing Stock Solutions for L-Quisqualic acid

The following data is based on the product molecular weight 189.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.29 mL 26.44 mL 52.87 mL
5 mM 1.06 mL 5.29 mL 10.57 mL
10 mM 0.53 mL 2.64 mL 5.29 mL
50 mM 0.11 mL 0.53 mL 1.06 mL

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Product Datasheets for L-Quisqualic acid

Certificate of Analysis / Product Datasheet
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References for L-Quisqualic acid

References are publications that support the biological activity of the product.

Littman et al (1995) Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus. Neuropharmacology 34 829 PMID: 8532164

Porter et al (1992) (S)-Homoquisqualate: a potent agonist at the glutamate metabotropic receptor. Br.J.Pharmacol. 106 509 PMID: 1324071

Schulte et al (1994) Utilization of the resolved L-isomer of 2-amino-6-phosphohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203 PMID: 7953634

If you know of a relevant reference for L-Quisqualic acid, please let us know.

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Keywords: L-Quisqualic acid, L-Quisqualic acid supplier, AMPA, group, I, mGlur, agonists, potent, Glutamate, Receptors, iGlur, Ionotropic, Group, mGlu1, mGlu5, mGluR1, mGluR5, Metabotropic, (Metabotropic), 0188, Tocris Bioscience

9 Citations for L-Quisqualic acid

Citations are publications that use Tocris products. Selected citations for L-Quisqualic acid include:

Shin et al (2018) Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo. Oncogenesis 7 86 PMID: 30425240

Wall et al (2014) Disruption of GRM1-mediated signalling using R.zole results in DNA damage in melanoma cells. Pigment Cell Melanoma Res 27 263 PMID: 24330389

Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236

Hu and Tu (2015) The roads to mitochondrial dysfunction in a rat model of posttraumatic syringomyelia. Biomed Res Int 2015 831490 PMID: 25685811

Do you know of a great paper that uses L-Quisqualic acid from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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