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Submit ReviewDL-AP4 Sodium salt
Description: Broad spectrum glutamatergic antagonist; sodium salt of DL-AP4 (Cat. No. 0101)
Chemical Name: DL-2-Amino-4-phosphonobutyric acid sodium salt
Purity: ≥99% (HPLC)
Biological Activity
Sodium salt of the broad spectrum EAA ligand DL-AP4.
Technical Data
| M. Wt | 205.08 |
| Formula | C4H9NNaO5P |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1263093-79-3 |
| PubChem ID | 52974248 |
| InChI Key | IGWPQOULJIILQQ-UHFFFAOYSA-M |
| Smiles | [Na+].NC(CCP(O)([O-])=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 20.51 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 205.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.88 mL | 24.38 mL | 48.76 mL |
| 5 mM | 0.98 mL | 4.88 mL | 9.75 mL |
| 10 mM | 0.49 mL | 2.44 mL | 4.88 mL |
| 50 mM | 0.1 mL | 0.49 mL | 0.98 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Evans et al (1979) Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog. Br.J.Pharmacol. 67 591 PMID: 316343
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024
If you know of a relevant reference for DL-AP4 Sodium salt, please let us know.
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Keywords: DL-AP4 Sodium salt, DL-AP4 Sodium salt supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Non-selective, mGlu, 3699, Tocris Bioscience
2 Citations for DL-AP4 Sodium salt
Citations are publications that use Tocris products. Selected citations for DL-AP4 Sodium salt include:
Sato and Kefalov (2016) cis Retinol oxidation regulates photoreceptor access to the retina visual cycle and cone pigment regeneration. J Physiol 594 6753 PMID: 27385534
Zhou et al (2015) Autophagy supports color vision. Autophagy 11 1821 PMID: 26292183
Do you know of a great paper that uses DL-AP4 Sodium salt from Tocris? Please let us know.
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