DL-AP4

Pricing Availability Delivery Time Qty
Cat.No. 0101 - DL-AP4 | C4H10NO5P | CAS No. 20263-07-4
Description: Broad spectrum EAA antagonist
Chemical Name: DL-2-Amino-4-phosphonobutyric acid
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Broad spectrum EAA ligand. Separate isomers D-AP4 and L-AP4 also available (Cat. No's. 0102 and 0103 respectively).

Technical Data

M. Wt 183.1
Formula C4H10NO5P
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 20263-07-4
PubChem ID 2207
InChI Key DDOQBQRIEWHWBT-UHFFFAOYSA-N
Smiles O=C(C(N)CCP(O)(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 6.04 33
1eq. HCl 18.31 100
1eq. NaOH 18.31 100
water 6.04 33

Preparing Stock Solutions

The following data is based on the product molecular weight 183.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.46 mL 27.31 mL 54.61 mL
5 mM 1.09 mL 5.46 mL 10.92 mL
10 mM 0.55 mL 2.73 mL 5.46 mL
50 mM 0.11 mL 0.55 mL 1.09 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Evans et al (1979) Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog. Br.J.Pharmacol. 67 591 PMID: 316343

Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024


If you know of a relevant reference for DL-AP4, please let us know.

View Related Products by Product Action

View all Non-selective Ionotropic Glutamate Antagonists

Keywords: DL-AP4, supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Non-selective, Ionotropic, Glutamate, Tocris Bioscience

3 Citations for DL-AP4

Citations are publications that use Tocris products. Selected citations for DL-AP4 include:

Schmidt and Kofuji (2011) Structure and function of bistratified intrinsically photosensitive retinal ganglion cells in the mouse. J Comp Neurol 519 1492 PMID: 21452206

Schmidt and Kofuji (2009) Functional and morphological differences among intrinsically photosensitive retinal ganglion cells. J Neurosci 29 476 PMID: 19144848

Sekaran et al (2005) Melanopsin-dependent photoreception provides earliest light detection in the mammalian retina. Curr Biol 15 1099 PMID: 15964274


Do you know of a great paper that uses DL-AP4 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for DL-AP4

Protocols

TODO: Add Protocols