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Biological Activity for DL-AP4
DL-AP4 is a broad spectrum EAA ligand.
Technical Data for DL-AP4
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DL-AP4
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for DL-AP4
The following data is based on the product molecular weight 183.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||10.92 mL||54.61 mL||109.23 mL|
|2.5 mM||2.18 mL||10.92 mL||21.85 mL|
|5 mM||1.09 mL||5.46 mL||10.92 mL|
|25 mM||0.22 mL||1.09 mL||2.18 mL|
References for DL-AP4
References are publications that support the biological activity of the product.
Evans et al (1979) Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog. Br.J.Pharmacol. 67 591 PMID: 316343
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024
If you know of a relevant reference for DL-AP4, please let us know.
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Keywords: DL-AP4, DL-AP4 supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, 20263-07-4, Non-selective, mGlu, 0101, Tocris Bioscience
6 Citations for DL-AP4
Citations are publications that use Tocris products. Selected citations for DL-AP4 include:
Sekaran et al (2005) Melanopsin-dependent photoreception provides earliest light detection in the mammalian retina. Curr Biol 15 1099 PMID: 15964274
Schmidt and Kofuji (2009) Functional and morphological differences among intrinsically photosensitive retinal ganglion cells. J Neurosci 29 476 PMID: 19144848
Vinberg et al (2015) A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease. Hum Mol Genet 24 5915 PMID: 26246500
Schmidt and Kofuji (2011) Structure and function of bistratified intrinsically photosensitive retinal ganglion cells in the mouse. J Comp Neurol 519 1492 PMID: 21452206
Ferlauto et al (2018) Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis. Nat Commun 9 992 PMID: 29520006
Chrispell et al (2018) Grk1b and Grk7a Both Contribute to the Recovery of the Isolated Cone Photoresponse in Larval Zebrafish. Invest Ophthalmol Vis Sci 59 5116 PMID: 30372740
Do you know of a great paper that uses DL-AP4 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.