DL-AP4

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Description: Broad spectrum glutamatergic antagonist
Chemical Name: DL-2-Amino-4-phosphonobutyric acid
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (1)

Biological Activity for DL-AP4

DL-AP4 is a broad spectrum EAA ligand.

D-isomer, L-isomer and Sodium Salt also available.

Technical Data for DL-AP4

M. Wt 183.1
Formula C4H10NO5P
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 6323-99-5
PubChem ID 2207
InChI Key DDOQBQRIEWHWBT-UHFFFAOYSA-N
Smiles O=C(C(N)CCP(O)(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DL-AP4

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.15 50

Preparing Stock Solutions for DL-AP4

The following data is based on the product molecular weight 183.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 10.92 mL 54.61 mL 109.23 mL
2.5 mM 2.18 mL 10.92 mL 21.85 mL
5 mM 1.09 mL 5.46 mL 10.92 mL
25 mM 0.22 mL 1.09 mL 2.18 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for DL-AP4

Certificate of Analysis / Product Datasheet
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References for DL-AP4

References are publications that support the biological activity of the product.

Evans et al (1979) Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog. Br.J.Pharmacol. 67 591 PMID: 316343

Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024


If you know of a relevant reference for DL-AP4, please let us know.

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Keywords: DL-AP4, DL-AP4 supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, 20263-07-4, Non-selective, mGlu, 0101, Tocris Bioscience

6 Citations for DL-AP4

Citations are publications that use Tocris products. Selected citations for DL-AP4 include:

Ferlauto et al (2018) Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis. Nat Commun 9 992 PMID: 29520006

Chrispell et al (2018) Grk1b and Grk7a Both Contribute to the Recovery of the Isolated Cone Photoresponse in Larval Zebrafish. Invest Ophthalmol Vis Sci 59 5116 PMID: 30372740

Schmidt and Kofuji (2011) Structure and function of bistratified intrinsically photosensitive retinal ganglion cells in the mouse. J Comp Neurol 519 1492 PMID: 21452206

Vinberg et al (2015) A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease. Hum Mol Genet 24 5915 PMID: 26246500


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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