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Description: Broad spectrum glutamatergic antagonist
Chemical Name: D-(-)-2-Amino-4-phosphonobutyric acid
Purity: ≥98% (HPLC)
Biological Activity for D-AP4
D-AP4 is a broad spectrum excitatory amino acid receptor antagonist. Also agonist at the quisqualate-sensitized AP6 site in hippocampus where it is less potent than L-AP4.
DL Mixture and L-isomer also available.
Technical Data for D-AP4
| M. Wt | 183.1 |
| Formula | C4H10NO5P |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 78739-01-2 |
| PubChem ID | 1550579 |
| InChI Key | DDOQBQRIEWHWBT-GSVOUGTGSA-N |
| Smiles | N[C@@]([H])([C@](O)=O)CCP(O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for D-AP4
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 100 |
Preparing Stock Solutions for D-AP4
The following data is based on the product molecular weight 183.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.46 mL | 27.31 mL | 54.61 mL |
| 5 mM | 1.09 mL | 5.46 mL | 10.92 mL |
| 10 mM | 0.55 mL | 2.73 mL | 5.46 mL |
| 50 mM | 0.11 mL | 0.55 mL | 1.09 mL |
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Product Datasheets for D-AP4
References for D-AP4
References are publications that support the biological activity of the product.
Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378 PMID: 6145492
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024
Schulte et al (1994) Utilization of the resolved L-isomer of 2-amino-6-phosphonhexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203 PMID: 7953634
If you know of a relevant reference for D-AP4, please let us know.
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Keywords: D-AP4, D-AP4 supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Non-selective, mGlu, 0102, Tocris Bioscience
3 Citations for D-AP4
Citations are publications that use Tocris products. Selected citations for D-AP4 include:
Sexton and Gelder (2015) G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells. PLoS One 10 e0128690 PMID: 26069965
France (2017) Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus. Neuropharmacology 112 76 PMID: 27523302
Sexton et al (2015) Type I intrinsically photosensitive retinal ganglion cells of early post-natal development correspond to the M4 subtype. Neural Dev 10 17 PMID: 26091805
Do you know of a great paper that uses D-AP4 from Tocris? Please let us know.
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