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D-AP4

Cat. No. 0102 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Broad spectrum glutamatergic antagonist
Chemical Name: D-(-)-2-Amino-4-phosphonobutyric acid
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for D-AP4

D-AP4 is a broad spectrum excitatory amino acid receptor antagonist. Also agonist at the quisqualate-sensitized AP6 site in hippocampus where it is less potent than L-AP4.

DL Mixture and L-isomer also available.

Technical Data for D-AP4

M. Wt 183.1
Formula C4H10NO5P
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 78739-01-2
PubChem ID 1550579
InChI Key DDOQBQRIEWHWBT-GSVOUGTGSA-N
Smiles N[C@@]([H])([C@](O)=O)CCP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for D-AP4

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 100

Preparing Stock Solutions for D-AP4

The following data is based on the product molecular weight 183.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.46 mL 27.31 mL 54.61 mL
5 mM 1.09 mL 5.46 mL 10.92 mL
10 mM 0.55 mL 2.73 mL 5.46 mL
50 mM 0.11 mL 0.55 mL 1.09 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for D-AP4

References are publications that support the biological activity of the product.

Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378 PMID: 6145492

Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024

Schulte et al (1994) Utilization of the resolved L-isomer of 2-amino-6-phosphonhexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203 PMID: 7953634

If you know of a relevant reference for D-AP4, please let us know.

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Keywords: D-AP4, D-AP4 supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Non-selective, mGlu, 0102, Tocris Bioscience

3 Citations for D-AP4

Citations are publications that use Tocris products. Selected citations for D-AP4 include:

Sexton et al (2015) Type I intrinsically photosensitive retinal ganglion cells of early post-natal development correspond to the M4 subtype. Neural Dev 10 17 PMID: 26091805

France (2017) Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus. Neuropharmacology 112 76 PMID: 27523302

Sexton and Gelder (2015) G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells. PLoS One 10 e0128690 PMID: 26069965

Do you know of a great paper that uses D-AP4 from Tocris? Please let us know.

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Literature in this Area

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