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(±)-Anatoxin A fumarate
Biological Activity for (±)-Anatoxin A fumarate
(±)-Anatoxin A fumarate is a potent nicotinic agonist (Ki values are 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors respectively). (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50 = 136 nM). (±)-Anatoxin A fumarate induces apoptosis in rat thymocytes and Vero cells by generation of reactive oxygen species and caspase activation.
Technical Data for (±)-Anatoxin A fumarate
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (±)-Anatoxin A fumarate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for (±)-Anatoxin A fumarate
The following data is based on the product molecular weight 281.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.55 mL||17.77 mL||35.55 mL|
|5 mM||0.71 mL||3.55 mL||7.11 mL|
|10 mM||0.36 mL||1.78 mL||3.55 mL|
|50 mM||0.07 mL||0.36 mL||0.71 mL|
Product Datasheets for (±)-Anatoxin A fumarate
References for (±)-Anatoxin A fumarate
References are publications that support the biological activity of the product.
Gordon et al (1992) Induced release of acetylcholine from guinea pig ileum longitudinal muscle myenteric plexus by anatoxin-A. J.Pharmacol.Exp.Ther. 263 997 PMID: 1469655
Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal DA release. J.Neurosci. 20 2783 PMID: 10751429
Stolerman et al (1992) Behavioural effects of anatoxin, a potent nicotinic agonist in rats. Neuropharmacology 31 311 PMID: 1630597
Thomas et al (1993) (+)-Anatoxin is a potent agonist at neuronal nicotinic acetylcholine receptors. J.Neurochem. 60 2308 PMID: 8492133
Lakshmana Rao et al (2002) Involvement of caspase and reactive oxygen species in cyanobacterial toxin anatoxin-a-induced cytotoxicity and apoptosis in rat thymocytes and Vero cells. Arch.Toxicol. 76 227 PMID: 12029386
Campos et al (2007) In vivo neurochemical characterization of Anatoxin-a evoked dopamine release from striatum. J.Neural Transm. 114 173 PMID: 16897603
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Keywords: (±)-Anatoxin A fumarate, (±)-Anatoxin A fumarate supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, nAChR, (±)-AnatoxinA, fumarate, (Non-selective), Apoptosis, Inducers, 0789, Tocris Bioscience
1 Citation for (±)-Anatoxin A fumarate
Citations are publications that use Tocris products. Selected citations for (±)-Anatoxin A fumarate include:
Gagnon and Pick (2012) Effect of nitrogen on cellular production and release of the neurotoxin anatoxin-a in a nitrogen-fixing cyanobacterium. Front Microbiol 3 211 PMID: 22701451
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Literature in this Area
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