(±)-Anatoxin A fumarate

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Cat.No. 0789 - (±)-Anatoxin A fumarate | C10H15NO.C4H4O4 | CAS No. 1219922-30-1
Description: Nicotinic agonist
Chemical Name: (±)-2-Acetyl-9-aza bicyclo[4.2.1]non-2-ene fumarate
Purity: ≥96% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

A potent nicotinic agonist (Ki values are 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors respectively). Stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50 = 136 nM).

Technical Data

M. Wt 281.31
Formula C10H15NO.C4H4O4
Storage Desiccate at +4°C
Purity ≥96% (HPLC)
CAS Number 1219922-30-1
PubChem ID 45073416
InChI Key ZJSIFVODFDHYJU-WLHGVMLRSA-N
Smiles O=C(C)C1=CCCC2CCC1N2.O=C(O)/C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 14.07 50

Preparing Stock Solutions

The following data is based on the product molecular weight 281.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.55 mL 17.77 mL 35.55 mL
5 mM 0.71 mL 3.55 mL 7.11 mL
10 mM 0.36 mL 1.78 mL 3.55 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gordon et al (1992) Induced release of acetylcholine from guinea pig ileum longitudinal muscle myenteric plexus by anatoxin-A. J.Pharmacol.Exp.Ther. 263 997 PMID: 1469655

Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal dopamine release. J.Neurosci. 20 2783 PMID: 10751429

Stolerman et al (1992) Behavioural effects of anatoxin, a potent nicotinic agonist in rats. Neuropharmacology 31 311 PMID: 1630597

Thomas et al (1993) (+)-Anatoxin is a potent agonist at neuronal nicotinic acetylcholine receptors. J.Neurochem. 60 2308 PMID: 8492133


If you know of a relevant reference for (±)-Anatoxin A fumarate, please let us know.

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View all Nicotinic Receptor (Non-selective) Agonists

Keywords: Nicotinic agonists Acetylcholine Receptors Non-Selective nAChR (±)-AnatoxinA fumarate Nicotinic Receptors (Non-selective)

1 Citation for (±)-Anatoxin A fumarate

Citations are publications that use Tocris products. Selected citations for (±)-Anatoxin A fumarate include:

Gagnon and Pick (2012) Effect of nitrogen on cellular production and release of the neurotoxin anatoxin-a in a nitrogen-fixing cyanobacterium. Front Microbiol 3 211 PMID: 22701451


Do you know of a great paper that uses (±)-Anatoxin A fumarate from Tocris? If so please let us know.

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Literature in this Area

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Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

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Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for (±)-Anatoxin A fumarate

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