(±)-Anatoxin A fumarate

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Description: nAChR agonist
Chemical Name: (±)-2-Acetyl-9-aza bicyclo[4.2.1]non-2-ene fumarate
Purity: ≥96% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity for (±)-Anatoxin A fumarate

(±)-Anatoxin A fumarate is a potent nicotinic agonist (Ki values are 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors respectively). (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50 = 136 nM). (±)-Anatoxin A fumarate induces apoptosis in rat thymocytes and Vero cells by generation of reactive oxygen species and caspase activation.

Technical Data for (±)-Anatoxin A fumarate

M. Wt 281.31
Formula C10H15NO.C4H4O4
Storage Store at +4°C
Purity ≥96% (HPLC)
CAS Number 1219922-30-1
PubChem ID 45073416
InChI Key ZJSIFVODFDHYJU-WLHGVMLRSA-N
Smiles O=C(C)C1=CCCC2CCC1N2.O=C(O)/C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (±)-Anatoxin A fumarate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 28.13 100

Preparing Stock Solutions for (±)-Anatoxin A fumarate

The following data is based on the product molecular weight 281.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.55 mL 17.77 mL 35.55 mL
5 mM 0.71 mL 3.55 mL 7.11 mL
10 mM 0.36 mL 1.78 mL 3.55 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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Product Datasheets for (±)-Anatoxin A fumarate

Certificate of Analysis / Product Datasheet
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References for (±)-Anatoxin A fumarate

References are publications that support the biological activity of the product.

Gordon et al (1992) Induced release of acetylcholine from guinea pig ileum longitudinal muscle myenteric plexus by anatoxin-A. J.Pharmacol.Exp.Ther. 263 997 PMID: 1469655

Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal DA release. J.Neurosci. 20 2783 PMID: 10751429

Stolerman et al (1992) Behavioural effects of anatoxin, a potent nicotinic agonist in rats. Neuropharmacology 31 311 PMID: 1630597

Thomas et al (1993) (+)-Anatoxin is a potent agonist at neuronal nicotinic acetylcholine receptors. J.Neurochem. 60 2308 PMID: 8492133

Lakshmana Rao et al (2002) Involvement of caspase and reactive oxygen species in cyanobacterial toxin anatoxin-a-induced cytotoxicity and apoptosis in rat thymocytes and Vero cells. Arch.Toxicol. 76 227 PMID: 12029386

Campos et al (2007) In vivo neurochemical characterization of Anatoxin-a evoked dopamine release from striatum. J.Neural Transm. 114 173 PMID: 16897603


If you know of a relevant reference for (±)-Anatoxin A fumarate, please let us know.

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Keywords: (±)-Anatoxin A fumarate, (±)-Anatoxin A fumarate supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, nAChR, (±)-AnatoxinA, fumarate, (Non-selective), Apoptosis, Inducers, 0789, Tocris Bioscience

1 Citation for (±)-Anatoxin A fumarate

Citations are publications that use Tocris products. Selected citations for (±)-Anatoxin A fumarate include:

Gagnon and Pick (2012) Effect of nitrogen on cellular production and release of the neurotoxin anatoxin-a in a nitrogen-fixing cyanobacterium. Front Microbiol 3 211 PMID: 22701451


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.