DIPPA hydrochloride

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Cat.No. 0794 - DIPPA hydrochloride | C22H23Cl2N3OS.HCl | CAS No. 155512-52-0
Description: Selective and irreversible κ antagonist
Chemical Name: 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (5)

Biological Activity

An irreversible and selective antagonist at the κ receptor, with persistent effect in vivo.

Technical Data

M. Wt 484.87
Formula C22H23Cl2N3OS.HCl
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 155512-52-0
PubChem ID 45073425
InChI Key BNWYENYHNOESCX-ZMBIFBSDSA-N
Smiles ClC1=C(Cl)C=C(CC(N([C@@](CN3CCCC3)([H])C2=CC=CC(N=C=S)=C2)C)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 14.55 30
DMSO 24.24 50

Preparing Stock Solutions

The following data is based on the product molecular weight 484.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.12 mL 20.62 mL 41.25 mL
2.5 mM 0.82 mL 4.12 mL 8.25 mL
5 mM 0.41 mL 2.06 mL 4.12 mL
25 mM 0.08 mL 0.41 mL 0.82 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Chang et al (1994) 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long lasting κ antagonism in mice. J.Med.Chem. 37 1547 PMID: 8201586

Chang et al (1994) κ opioid receptor selective affinity labels: Electrophilic benzeneacetamides as κ-selective opioid antagonists. J.Med.Chem. 37 4490 PMID: 7799399


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Keywords: DIPPA hydrochloride, DIPPA hydrochloride supplier, Selective, irreversible, κ-opioid, kappa-opioid, antagonists, KOP, Receptors, OP2, Kappa, Opioid, 0794, Tocris Bioscience

2 Citations for DIPPA hydrochloride

Citations are publications that use Tocris products. Selected citations for DIPPA hydrochloride include:

Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID: 20696141

Carr and Lucki (2010) Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats. Psychopharmacology (Berl) 210 295 PMID: 20369354


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Literature in this Area

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