DIPPA hydrochloride

Pricing Availability   Qty
Description: Selective and irreversible κ antagonist
Chemical Name: 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
Purity: ≥99% (HPLC)
Citations (2)
Literature (2)

Biological Activity for DIPPA hydrochloride

DIPPA hydrochloride is an an irreversible and selective antagonist at the κ receptor, with persistent effect in vivo.

Technical Data for DIPPA hydrochloride

M. Wt 484.87
Formula C22H23Cl2N3OS.HCl
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 155512-52-0
PubChem ID 45073425
Smiles ClC1=C(Cl)C=C(CC(N([C@@](CN3CCCC3)([H])C2=CC=CC(N=C=S)=C2)C)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DIPPA hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 14.55 30
DMSO 24.24 50

Preparing Stock Solutions for DIPPA hydrochloride

The following data is based on the product molecular weight 484.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.12 mL 20.62 mL 41.25 mL
2.5 mM 0.82 mL 4.12 mL 8.25 mL
5 mM 0.41 mL 2.06 mL 4.12 mL
25 mM 0.08 mL 0.41 mL 0.82 mL

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Product Datasheets for DIPPA hydrochloride

Certificate of Analysis / Product Datasheet
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References for DIPPA hydrochloride

References are publications that support the biological activity of the product.

Chang et al (1994) 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long lasting κ antagonism in mice. J.Med.Chem. 37 1547 PMID: 8201586

Chang et al (1994) κ opioid receptor selective affinity labels: Electrophilic benzeneacetamides as κ-selective opioid antagonists. J.Med.Chem. 37 4490 PMID: 7799399

If you know of a relevant reference for DIPPA hydrochloride, please let us know.

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Keywords: DIPPA hydrochloride, DIPPA hydrochloride supplier, Selective, irreversible, κ-opioid, kappa-opioid, antagonists, KOP, Receptors, OP2, Kappa, Opioid, 0794, Tocris Bioscience

2 Citations for DIPPA hydrochloride

Citations are publications that use Tocris products. Selected citations for DIPPA hydrochloride include:

Carr and Lucki (2010) Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats. Psychopharmacology (Berl) 210 295 PMID: 20369354

Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID: 20696141

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

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Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.