DIPPA hydrochloride

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Cat.No. 0794 - DIPPA hydrochloride | C22H23Cl2N3OS.HCl | CAS No. 155512-52-0
Description: Selective irreversible κ antagonist
Chemical Name: 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

An irreversible and selective antagonist at the κ receptor, with persistent effect in vivo.

Technical Data

M. Wt 484.87
Formula C22H23Cl2N3OS.HCl
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 155512-52-0
PubChem ID 45073425
InChI Key BNWYENYHNOESCX-ZMBIFBSDSA-N
Smiles ClC1=C(Cl)C=C(CC(N([C@@](CN3CCCC3)([H])C2=CC=CC(N=C=S)=C2)C)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.24 50
ethanol 14.55 30

Preparing Stock Solutions

The following data is based on the product molecular weight 484.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.06 mL 10.31 mL 20.62 mL
5 mM 0.41 mL 2.06 mL 4.12 mL
10 mM 0.21 mL 1.03 mL 2.06 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chang et al (1994) 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long lasting κ antagonism in mice. J.Med.Chem. 37 1547 PMID: 8201586

Chang et al (1994) κ opioid receptor selective affinity labels: Electrophilic benzeneacetamides as κ-selective opioid antagonists. J.Med.Chem. 37 4490 PMID: 7799399


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View all κ Opioid Receptor Antagonists

Keywords: Selective irreversible κ-opioid kappa-opioid antagonists KOP Receptors OP2 Kappa Opioid Receptors

1 Citation for DIPPA hydrochloride

Citations are publications that use Tocris products. Selected citations for DIPPA hydrochloride include:

Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID: 20696141


Do you know of a great paper that uses DIPPA hydrochloride from Tocris? If so please let us know.

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