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An irreversible and selective antagonist at the κ receptor, with persistent effect in vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 484.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.12 mL||20.62 mL||41.25 mL|
|2.5 mM||0.82 mL||4.12 mL||8.25 mL|
|5 mM||0.41 mL||2.06 mL||4.12 mL|
|25 mM||0.08 mL||0.41 mL||0.82 mL|
References are publications that support the biological activity of the product.
Chang et al (1994) 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long lasting κ antagonism in mice. J.Med.Chem. 37 1547 PMID: 8201586
Chang et al (1994) κ opioid receptor selective affinity labels: Electrophilic benzeneacetamides as κ-selective opioid antagonists. J.Med.Chem. 37 4490 PMID: 7799399
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Keywords: DIPPA hydrochloride, DIPPA hydrochloride supplier, Selective, irreversible, κ-opioid, kappa-opioid, antagonists, KOP, Receptors, OP2, Kappa, Opioid, 0794, Tocris Bioscience
2 Citations for DIPPA hydrochloride
Citations are publications that use Tocris products. Selected citations for DIPPA hydrochloride include:
Carr and Lucki (2010) Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats. Psychopharmacology (Berl) 210 295 PMID: 20369354
Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID: 20696141
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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