An irreversible and selective antagonist at the κ receptor, with persistent effect in vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 484.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.06 mL||10.31 mL||20.62 mL|
|5 mM||0.41 mL||2.06 mL||4.12 mL|
|10 mM||0.21 mL||1.03 mL||2.06 mL|
|50 mM||0.04 mL||0.21 mL||0.41 mL|
References are publications that support the products' biological activity.
Chang et al (1994) 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long lasting κ antagonism in mice. J.Med.Chem. 37 1547 PMID: 8201586
Chang et al (1994) κ opioid receptor selective affinity labels: Electrophilic benzeneacetamides as κ-selective opioid antagonists. J.Med.Chem. 37 4490 PMID: 7799399
If you know of a relevant reference for DIPPA hydrochloride, please let us know.
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Keywords: DIPPA hydrochloride, supplier, Selective, irreversible, κ-opioid, kappa-opioid, antagonists, KOP, Receptors, OP2, Kappa, Opioid, Receptors, Kappa, Opioid, Receptors, Tocris Bioscience
1 Citation for DIPPA hydrochloride
Citations are publications that use Tocris products. Selected citations for DIPPA hydrochloride include:
Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID: 20696141
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