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Cat.No. 6377 - DIM-C-pPhOH | C23H18N2O | CAS No. 151358-47-3
Description: Nur77 antagonist
Chemical Name: 1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane
Purity: ≥98% (HPLC)

Biological Activity

Nur77 (NR4A1) antagonist. Inhibits TGF-β induced cell migration of breast cancer cell lines. Promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines. Mimics effects of Nur77 RNAi silencing.

Technical Data

M. Wt 338.408
Formula C23H18N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 151358-47-3
PubChem ID 2940609
Smiles OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.84 100
ethanol 33.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 338.408. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.55 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Safety Datasheet


References are publications that support the biological activity of the product.

Chintharlapalli et al (2005) Activation of Nur77 by selected 1,1-Bis(3-indolyl)-1- (p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J.Biol.Chem 280 24903 PMID: 15871945

Hedrick et al (2016) NR4A1 antagonists inhibit 1-Integrin-dependent breast cancer cell migration. Mol.Cell.Biol 36 1383 PMID: 26929200

Lee et al (2014) The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Mol.Cancer Res. 12 527 PMID: 24515801

If you know of a relevant reference for DIM-C-pPhOH, please let us know.

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