Pricing Availability   Qty
Description: Nur77 antagonist
Chemical Name: 1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane
Purity: ≥98% (HPLC)
Literature (1)
Pathways (1)

Biological Activity for DIM-C-pPhOH

DIM-C-pPhOH is a Nur77 (NR4A1) antagonist. Inhibits TGF-β induced cell migration of breast cancer cell lines. Promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines. Mimics effects of Nur77 RNAi silencing.

Technical Data for DIM-C-pPhOH

M. Wt 338.408
Formula C23H18N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 151358-47-3
PubChem ID 2940609
Smiles OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DIM-C-pPhOH

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.84 100
ethanol 33.84 100

Preparing Stock Solutions for DIM-C-pPhOH

The following data is based on the product molecular weight 338.408. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.55 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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References for DIM-C-pPhOH

References are publications that support the biological activity of the product.

Chintharlapalli et al (2005) Activation of Nur77 by selected 1,1-Bis(3-indolyl)-1- (p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J.Biol.Chem 280 24903 PMID: 15871945

Hedrick et al (2016) NR4A1 antagonists inhibit 1-Integrin-dependent breast cancer cell migration. Mol.Cell.Biol 36 1383 PMID: 26929200

Lee et al (2014) The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Mol.Cancer Res. 12 527 PMID: 24515801

If you know of a relevant reference for DIM-C-pPhOH, please let us know.

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Citations for DIM-C-pPhOH

Citations are publications that use Tocris products.

Currently there are no citations for DIM-C-pPhOH. Do you know of a great paper that uses DIM-C-pPhOH from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for DIM-C-pPhOH

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.
NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.