Nur77 (NR4A1) antagonist. Inhibits TGF-β induced cell migration of breast cancer cell lines. Promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines. Mimics effects of Nur77 RNAi silencing.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 338.408. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.96 mL||14.78 mL||29.55 mL|
|5 mM||0.59 mL||2.96 mL||5.91 mL|
|10 mM||0.3 mL||1.48 mL||2.96 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
References are publications that support the biological activity of the product.
Chintharlapalli et al (2005) Activation of Nur77 by selected 1,1-Bis(3-indolyl)-1- (p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J.Biol.Chem 280 24903 PMID: 15871945
Hedrick et al (2016) NR4A1 antagonists inhibit 1-Integrin-dependent breast cancer cell migration. Mol.Cell.Biol 36 1383 PMID: 26929200
Lee et al (2014) The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Mol.Cancer Res. 12 527 PMID: 24515801
If you know of a relevant reference for DIM-C-pPhOH, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: DIM-C-pPhOH, DIM-C-pPhOH supplier, Nur77, antagonists, antagonism, nuclear, receptor, proapoptotic, cancer, cell, migration, inhibitors, inhibits, Other, Nuclear, Receptors, 6377, Tocris Bioscience
Citations for DIM-C-pPhOH
Citations are publications that use Tocris products.
Currently there are no citations for DIM-C-pPhOH. Do you know of a great paper that uses DIM-C-pPhOH from Tocris? Please let us know.
Reviews for DIM-C-pPhOH
There are currently no reviews for this product. Be the first to review DIM-C-pPhOH and earn rewards!
Have you used DIM-C-pPhOH?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.