Dihydro-β-erythroidine hydrobromide

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Cat.No. 2349 - Dihydro-b-erythroidine hydrobromide | C16H21NO3.HBr | CAS No. 29734-68-7
Description: Inhibitor of α4β2, muscle type and Torepedo nAChRs
Alternative Names: DHβE
Chemical Name: (2S,13bS)-2-Methoxy-2,3,5,6,8,9,10,13-octahydro-1H,12H-benzo[i]pyrano[3,4-g]indolizin-12-one hydrobromide
Purity: ≥98% (HPLC)
Datasheet
Citations (20)
Literature

Biological Activity

Competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α4 receptor subunit (IC50 values are 0.19 and 0.37 μM for α4β4 and α4β2 receptors respectively). Antagonizes behavioral effects of nicotine in vivo.

Technical Data

M. Wt 356.26
Formula C16H21NO3.HBr
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 29734-68-7
PubChem ID 11957537
InChI Key GFIGWAJEIMHJJB-LINSIKMZSA-N
Smiles O=C1CC2=C(CCN4[C@]32C(CC4)=CC[C@H](OC)C3)CO1.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.91 25
water 35.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 356.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.03 mL 28.07 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
10 mM 0.28 mL 1.4 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Williams and Robinson (1984) Binding of the nicotinic cholinergic antagonist, dihydro-β-erythroidine, to rat brain tissue. J.Neurosci. 4 2906 PMID: 6502210

Damaj et al (1995) In vivo pharmacological effects of dihydro-β-erythroidine, a nicotinic antagonist, in mice. Psychopharmacology 117 67 PMID: 7724704

Harvey et al (1996) Multiple determinants of dihydro-β-erythroidine sensitivity on rat neuronal nicotinic receptor #945; subunits. J.Neurochem. 67 1953 PMID: 8863500


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View Related Products by Product Action

View all Nicotinic Receptor (Other Subtype) Antagonists

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20 Citations for Dihydro-β-erythroidine hydrobromide

Citations are publications that use Tocris products. Selected citations for Dihydro-β-erythroidine hydrobromide include:

Assous (2017) Differential processing of thalamic information via distinct striatal interneuron circuits. Nat Commun 8 15860 PMID: 28604688

Miguel Angel Garcia-Bereguiain et al (2016) Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo The Journal of Neuroscience 6 7268 PMID: 27383600

Herman et al (2016) A cholinergic basal forebrain feeding circuit modulates appetite suppression Nature 538 253 PMID: 27698417

Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission Scientific Reports 6 37834 PMID: 27886263

Kunisawa et al (2016) Nicotine evokes kinetic tremor by activating the inferior olive via α7 nicotinic acetylcholine receptors. Behav.Brain Res. 314 173 PMID: 27506652

Dilger et al (2015) Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. J Neurosci 35 3652 PMID: 25716863

Stouffer et al (2015) Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun 6 8543 PMID: 26503322

Saunders et al (2015) Corelease of acetylcholine and GABA from cholinergic forebrain neurons. J Neurosci 4 PMID: 25723967

Ngolab et al (2015) Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward. J Neurosci 35 8570 PMID: 26041923

Yorgason et al (2015) Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: Role of nicotinic acetylcholine receptors. Front Cell Neurosci 284 854 PMID: 25451295

Elgueta et al (2015) Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. PLoS One 9 6 PMID: 25709566

Bader and Diener (2015) Novel aspects of cholinergic regulation of colonic ion transport. Elife 3 e00139 PMID: 26236483

Morrie and Feller (2015) An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina. Neuroscience 35 9281 PMID: 26109653

Kiss et al (2014) Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS One 9 e109538 PMID: 25303328

Zhong et al (2013) Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. Pharmacol Res Perspect 8 e82719 PMID: 24349346

Platt et al (2012) Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice. PLoS One 7 e36397 PMID: 22570709

Caiati et al (2012) Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep 2 285 PMID: 22368777

Goddard et al (2012) Gamma oscillations are generated locally in an attention-related midbrain network. Neuron 73 567 PMID: 22325207

Li et al (2010) Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors. Auton Neurosci 154 14 PMID: 19887306

Li et al (2009) Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses. Neurosci Lett 462 20 PMID: 19573576


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