Desmethyl-YM 298198

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Cat.No. 2447 - Desmethyl-YM 298198 | C17H20N4OS.HCl | CAS No. 1177767-57-5
Description: Derivative of mGlu1 antagonist YM 298198 (Cat. No. 2448)
Chemical Name: 6-Amino-N-cyclohexyl-3-methylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Derivative of the mGlu1-selective antagonist YM 298198 (Cat. No. 2448).

Licensing Information

Sold with the permission of Astellas Pharma Inc.

Technical Data

M. Wt 364.89
Formula C17H20N4OS.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1177767-57-5
PubChem ID 16759180
InChI Key SWKZWXJQIDXGLX-UHFFFAOYSA-N
Smiles Cl.CC1=C(SC2=NC3=CC=C(N)C=C3N12)C(=O)NC1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.24 50

Preparing Stock Solutions

The following data is based on the product molecular weight 364.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.7 mL 27.41 mL
5 mM 0.55 mL 2.74 mL 5.48 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kohara et al (2005) Radioligand binding properties and pharmacological characterization of 6-Amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]-benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective and noncompetitive antagonist of metabo J.Pharmacol.Exp.Ther. 315 163 PMID: 15976016


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Citations for Desmethyl-YM 298198

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