Discontinued Product

Desloratadine (Cat. No. 5958) has been withdrawn from sale for commercial reasons.
Description: High affinity H1 antagonist; anti-inflammatory
Chemical Name: 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for Desloratadine

Desloratadine is a high affinity histamine H1 receptor antagonist (Ki = 0.87 nM); active metabolite of loratadine (Cat. No. 1944). Anti-inflammatory.

Technical Data for Desloratadine

M. Wt 310.82
Formula C19H19ClN2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 100643-71-8
PubChem ID 124087
Smiles ClC1=CC=C2C(CCC3=C(/C2=C4CCNCC\4)N=CC=C3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Desloratadine

References for Desloratadine

References are publications that support the biological activity of the product.

Henz (2001) The pharmacologic profile of desloratadine: a review. Allergy 56 7 PMID: 11243504

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Citations for Desloratadine

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Currently there are no citations for Desloratadine.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.