Desloratadine

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Cat.No. 5958 - Desloratadine | C19H19ClN2 | CAS No. 100643-71-8
Description: High affinity H1 antagonist; anti-inflammatory
Chemical Name: 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity histamine H1 receptor antagonist (Ki = 0.87 nM); active metabolite of loratadine (Cat. No. 1944). Anti-inflammatory.

Technical Data

M. Wt 310.82
Formula C19H19ClN2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 100643-71-8
PubChem ID 124087
InChI Key JAUOIFJMECXRGI-UHFFFAOYSA-N
Smiles ClC1=CC=C2C(CCC3=C(/C2=C4CCNCC\4)N=CC=C3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.22 20
ethanol 31.08 100

Preparing Stock Solutions

The following data is based on the product molecular weight 310.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.22 mL 16.09 mL 32.17 mL
5 mM 0.64 mL 3.22 mL 6.43 mL
10 mM 0.32 mL 1.61 mL 3.22 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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References

References are publications that support the biological activity of the product.

Henz (2001) The pharmacologic profile of desloratadine: a review. Allergy 56 7 PMID: 11243504


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