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Cat.No. 5958 - Desloratadine | C19H19ClN2 | CAS No. 100643-71-8
Description: High affinity H1 antagonist; anti-inflammatory
Chemical Name: 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Purity: ≥99% (HPLC)
Literature (3)

Biological Activity for Desloratadine

Desloratadine is a high affinity histamine H1 receptor antagonist (Ki = 0.87 nM); active metabolite of loratadine (Cat. No. 1944). Anti-inflammatory.

Technical Data for Desloratadine

M. Wt 310.82
Formula C19H19ClN2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 100643-71-8
PubChem ID 124087
Smiles ClC1=CC=C2C(CCC3=C(/C2=C4CCNCC\4)N=CC=C3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Desloratadine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 6.22 20
ethanol 31.08 100

Preparing Stock Solutions for Desloratadine

The following data is based on the product molecular weight 310.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.22 mL 16.09 mL 32.17 mL
5 mM 0.64 mL 3.22 mL 6.43 mL
10 mM 0.32 mL 1.61 mL 3.22 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets for Desloratadine

References for Desloratadine

References are publications that support the biological activity of the product.

Henz (2001) The pharmacologic profile of desloratadine: a review. Allergy 56 7 PMID: 11243504

If you know of a relevant reference for Desloratadine, please let us know.

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