Desloratadine

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Cat.No. 5958 - Desloratadine | C19H19ClN2 | CAS No. 100643-71-8
Description: High affinity H1 antagonist; anti-inflammatory.
Chemical Name: 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity histamine H1 receptor antagonist (Ki = 0.87 nM); active metabolite of loratadine (Cat. No. 1944). Anti-inflammatory.

Technical Data

M. Wt 310.82
Formula C19H19ClN2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 100643-71-8
PubChem ID 124087
InChI Key JAUOIFJMECXRGI-UHFFFAOYSA-N
Smiles ClC1=CC=C2C(CCC3=C(/C2=C4CCNCC\4)N=CC=C3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.22 20
ethanol 31.08 100

Preparing Stock Solutions

The following data is based on the product molecular weight 310.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.22 mL 16.09 mL 32.17 mL
5 mM 0.64 mL 3.22 mL 6.43 mL
10 mM 0.32 mL 1.61 mL 3.22 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Henz (2001) The pharmacologic profile of desloratadine: a review. Allergy 56 7 PMID: 11243504


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Keywords: Desloratadine, supplier, histamine, H1, receptors, antagonists, histaminergic, anti-inflammatory, hay, fever, allergic, rhinitis, chornic, urticaria, Histamine, H1, Receptors, Histamine, H1, Receptors, Tocris Bioscience

Citations for Desloratadine

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Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.

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