Desformylflustrabromine hydrochloride

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Positive allosteric modulator of α4β2 nAChRs; also muscle-type nAChR inhibitor
Chemical Name: 6-Bromo-2-(1,1-dimethyl-2-propenyl)-N-1H-indole-3-ethanamine hydrochloride
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Desformylflustrabromine hydrochloride

Desformylflustrabromine hydrochloride is a positive allosteric modulator of nicotinic α4β2 receptors; selectively increases the ionic current through α4β2 in the presence of ACh. Displays 14.7-fold selectivity for α4β2 over homomeric (α7) receptors. Moderately cytotoxic in HCT-116 cells. Also inhibits human muscle (αβεδ) and Torpedo (αβγδ) nAChRs (IC50 values are 1.0 and 0.1 μM, respectively) by binding in the ion channel.

Technical Data for Desformylflustrabromine hydrochloride

M. Wt 357.72
Formula C16H21BrN2.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 951322-11-5
PubChem ID 56675778
Smiles CNCCC2=C(C(C)(C)C=C)NC1=CC(Br)=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Desformylflustrabromine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.77 100
water 3.58 10 with gentle warming

Preparing Stock Solutions for Desformylflustrabromine hydrochloride

The following data is based on the product molecular weight 357.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.8 mL 13.98 mL 27.95 mL
5 mM 0.56 mL 2.8 mL 5.59 mL
10 mM 0.28 mL 1.4 mL 2.8 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Desformylflustrabromine hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for Desformylflustrabromine hydrochloride

References are publications that support the biological activity of the product.

Kim et al (2007) Synthesis of desformylflustrabromine and its evaluation as an α4β2 and α7 nACh receptor modulator. Bioorg.Med.Chem.Lett. 17 4855 PMID: 17604168

Sala et al (2005) Potentiation of human α4β2 neuronal nicotinic receptors by a Flustra foliacea metabolite. Neurosci.Lett. 373 44

Weltzin and Schulte (2010) Pharmacological characterization of the allosteric modulator desformylflustrabromine and its interaction with α4β2 neuronal nicotinic acetylcholine receptor orthosteric ligands. J.Pharm.Exp.Ther. 334 917

Hamouda et al (2015) Desformylflustrabromine (dFBr) and [3H]dFBr-labeled binding sites in a nicotinic acetylcholine receptor. Mol.Pharmacol. 88 1 PMID: 25870334

If you know of a relevant reference for Desformylflustrabromine hydrochloride, please let us know.

View Related Products by Product Action

View all Nicotinic (α4β2) Receptor Modulators

Keywords: Desformylflustrabromine hydrochloride, Desformylflustrabromine hydrochloride supplier, dFBr, a4b2, nicotinic, acetylcholine, receptor, receptors, nAChR, positive, allosteric, modulators, PAM, Nicotinic, (a4b2), Receptors, (Other, Subtypes), 3328, Tocris Bioscience

Citations for Desformylflustrabromine hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Desformylflustrabromine hydrochloride. Do you know of a great paper that uses Desformylflustrabromine hydrochloride from Tocris? Please let us know.

Reviews for Desformylflustrabromine hydrochloride

There are currently no reviews for this product. Be the first to review Desformylflustrabromine hydrochloride and earn rewards!

Have you used Desformylflustrabromine hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.