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ERK dimerization inhibitor (IC50 ~ 0.5 μM); inhibits ERK dimerization without affecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro. Induces apoptosis and prevents tumor progression in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 444.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.5 mL||22.5 mL||44.99 mL|
|2.5 mM||0.9 mL||4.5 mL||9 mL|
|5 mM||0.45 mL||2.25 mL||4.5 mL|
|25 mM||0.09 mL||0.45 mL||0.9 mL|
References are publications that support the biological activity of the product.
Herrero et al (2015) Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes. Cancer Cell 28 170 PMID: 26267534
Ryan et al (2015) Targeting RAS-mutant cancers: is ERK the key? Trends Cancer 1 183 PMID: 26858988
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Keywords: DEL 22379, DEL 22379 supplier, ERK, dimerization, inhibitors, inhibits, extracellular, signal, related, kinase, RAS, 5774, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.