DEL 22379

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Description: ERK dimerization inhibitor
Chemical Name: N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Pathways (1)

Biological Activity for DEL 22379

DEL 22379 is an ERK dimerization inhibitor (IC50 ~ 0.5 μM); inhibits ERK dimerization without affecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro. Induces apoptosis and prevents tumor progression in vivo.

Technical Data for DEL 22379

M. Wt 444.53
Formula C26H28N4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 181223-80-3
PubChem ID 11224574
InChI Key INQUULPXCZAKMS-XKZIYDEJSA-N
Smiles O=C1NC2=CC=C(NC(CCN3CCCCC3)=O)C=C2/C1=C/C4=CNC5=C4C=C(OC)C=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DEL 22379

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.23 50

Preparing Stock Solutions for DEL 22379

The following data is based on the product molecular weight 444.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.5 mL 22.5 mL 44.99 mL
2.5 mM 0.9 mL 4.5 mL 9 mL
5 mM 0.45 mL 2.25 mL 4.5 mL
25 mM 0.09 mL 0.45 mL 0.9 mL

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References for DEL 22379

References are publications that support the biological activity of the product.

Herrero et al (2015) Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes. Cancer Cell 28 170 PMID: 26267534

Ryan et al (2015) Targeting RAS-mutant cancers: is ERK the key? Trends Cancer 1 183 PMID: 26858988


If you know of a relevant reference for DEL 22379, please let us know.

View Related Products by Target

Keywords: DEL 22379, DEL 22379 supplier, ERK, dimerization, inhibitors, inhibits, extracellular, signal, related, kinase, RAS, 5774, Tocris Bioscience

1 Citation for DEL 22379

Citations are publications that use Tocris products. Selected citations for DEL 22379 include:

Saranya Santhosh et al (2019) The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER. Cell 179 1306-1318.e18 PMID: 31761535


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Reviews for DEL 22379

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for DEL 22379

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.