Decanoyl-RVKR-CMK

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Cat.No. 3501 - Decanoyl-RVKR-CMK | Decanoyl-Arg-Val-Lys-Arg-chloromethyl ketone | CAS No. 150113-99-8
Description: Subtilisin/Kex2p-like proprotein convertase inhibitor
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells.

Technical Data

M. Wt 744.42
Formula C34H66ClN11O5
Sequence RVKR

(Modifications: Arg-1 = Decanoyl-Arg, Arg-4 = chlororomethylketone)

Storage Store at -20°C
CAS Number 150113-99-8
PubChem ID 9962075
InChI Key NHBJTTGFHCHQHS-VZTVMPNDSA-N
Smiles [H]N([C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CCl)C(=O)CCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 744.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.34 mL 6.72 mL 13.43 mL
5 mM 0.27 mL 1.34 mL 2.69 mL
10 mM 0.13 mL 0.67 mL 1.34 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Garcia et al (2005) A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J.Biol.Chem. 280 41595 PMID: 16221685

Tian and Jianhua (2010) Comparative study of the binding pocket of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors. Int.J.Biol.Sci. 6 89 PMID: 20151049

Denault et al (1995) Inhibition of convertase-related processing of proendothelin-1. J.Cardiovasc.Pharmacol. 26 S47 PMID: 8587448


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Keywords: Decanoyl-RVKR-CMK, supplier, proprotein, convertases, inhibitors, inhibits, supplier, proteolytic, cleavage, calcium, dependent, serine, endopeptidases, furin, PC1, PC2, PC4, PACE4, PC5, PC7, secretory, pathway, Other, Proteases, Other, Proteases, Tocris Bioscience

1 Citation for Decanoyl-RVKR-CMK

Citations are publications that use Tocris products. Selected citations for Decanoyl-RVKR-CMK include:

Edin (2014) The role of interleukin-13 in the removal of hyper-radiosensitivity by priming irradiation. Am J Physiol Gastrointest Liver Physiol 55 1066 PMID: 24966400


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