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Submit ReviewDC 432 is a potent peptidomimetic inhibitor of N-terminal methyltransferase 1/2 (NTMT1/2) (IC50 = 54 nM). Comprises a BM30 peptide with five additional arginine residues. DC 432 treatment in HCT116 cells decreases the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins. Cell permeable.
M. Wt | 1313.59 |
Formula | C55H100N28O10 |
Sequence |
PKRRRRRR (Modifications:Pro-1 = 4-Hydroxyphenylacetyl-Pro; C-terminal amide) |
Storage | Store at -20°C |
Purity | ≥95% (HPLC) |
CAS Number | 2388988-70-1 |
InChI Key | UVDZRYDWESJRQX-ZHECQJHESA-N |
Smiles | O=C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)[C@@H]1N(C(CC2=CC=C(O)C=C2)=O)CCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility | Soluble to 2 mg/ml in water |
References are publications that support the biological activity of the product.
Mackie et al (2020) Selective peptidomimetic inhibitors of NTMT1/2: rational design, synthesis, characterization, and crystallographic studies. J.Med.Chem. 63 9512 PMID: 32689795
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Keywords: DC 432, DC 432 supplier, DC432, BM30, potent, peptidomimetic, Inhibitors, Inhibition, inhibits, N-terminal, methyltransferase1/2, NTMT1/2, Post-translational, Modifications, Mitosis, 7907, Tocris Bioscience
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