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DC 432 New
Biological Activity for DC 432
DC 432 is a potent peptidomimetic inhibitor of N-terminal methyltransferase 1/2 (NTMT1/2) (IC50 = 54 nM). Comprises a BM30 peptide with five additional arginine residues. DC 432 treatment in HCT116 cells decreases the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins. Cell permeable.
Technical Data for DC 432
(Modifications:Pro-1 = 4-Hydroxyphenylacetyl-Pro; C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DC 432
|Solubility||Soluble to 2 mg/ml in water|
References for DC 432
References are publications that support the biological activity of the product.
Mackie et al (2020) Selective peptidomimetic inhibitors of NTMT1/2: rational design, synthesis, characterization, and crystallographic studies. J.Med.Chem. 63 9512 PMID: 32689795
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Keywords: DC 432, DC 432 supplier, DC432, BM30, potent, peptidomimetic, Inhibitors, Inhibition, inhibits, N-terminal, methyltransferase1/2, NTMT1/2, Post-translational, Modifications, Mitosis, 7907, Tocris Bioscience
Citations for DC 432
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Literature in this Area
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