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DC 432

Cat. No. 7907 Submit a Review Datasheet / COA / SDS
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Description: Potent peptidomimetic inhibitor of N-terminal methyltransferase 1/2
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for DC 432

DC 432 is a potent peptidomimetic inhibitor of N-terminal methyltransferase 1/2 (NTMT1/2) (IC50 = 54 nM). Comprises a BM30 peptide with five additional arginine residues. DC 432 treatment in HCT116 cells decreases the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins. Cell permeable.

Technical Data for DC 432

M. Wt 1313.59
Formula C55H100N28O10
Sequence PKRRRRRR

(Modifications:Pro-1 = 4-Hydroxyphenylacetyl-Pro; C-terminal amide)
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2388988-70-1
InChI Key UVDZRYDWESJRQX-ZHECQJHESA-N
Smiles O=C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)[C@@H]1N(C(CC2=CC=C(O)C=C2)=O)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DC 432

Solubility Soluble to 2 mg/ml in water

References for DC 432

References are publications that support the biological activity of the product.

Mackie et al (2020) Selective peptidomimetic inhibitors of NTMT1/2: rational design, synthesis, characterization, and crystallographic studies. J.Med.Chem. 63 9512 PMID: 32689795

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Citations for DC 432

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