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Cat.No. 6606 - dBRD9 | C40H45N7O10.2HCl
Description: Potent and selective BRD9 degrading PROTAC
Chemical Name: 2-[[[4-(1,2-Dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2-6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]acetamide dihydrochloride
Purity: ≥98% (HPLC)

Biological Activity

PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide (Cat. No. 6302). Potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). Does not degrade BRD4 or BRD7 at concentrations up to 5 μM. Displays antiproliferative effects in human AML cell lines.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Technical Data

M. Wt 856.75
Formula C40H45N7O10.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 135397681

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 17.14 20
DMSO 42.84 50

Preparing Stock Solutions

The following data is based on the product molecular weight 856.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.33 mL 11.67 mL 23.34 mL
2.5 mM 0.47 mL 2.33 mL 4.67 mL
5 mM 0.23 mL 1.17 mL 2.33 mL
25 mM 0.05 mL 0.23 mL 0.47 mL

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References are publications that support the biological activity of the product.

Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID: 28418626

If you know of a relevant reference for dBRD9, please let us know.

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