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Cat.No. 6710 - Darunavir | C27H37N3O7S | CAS No. 206361-99-1
Description: Highly potent HIV protease inhibitor
Chemical Name: (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamate
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Highly potent HIV protease inhibitor (IC50 = 3 - 6 nM, depending on laboratory HIV-1 strain). Displays activity in cells infected with clinical HIV-1 strains shown to have resistance to other protease inhibitors.

Technical Data

M. Wt 547.66
Formula C27H37N3O7S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 206361-99-1
PubChem ID 213039
Smiles [H][C@@]12CCO[C@@]1(OC[C@@H]2OC(N[C@H]([C@@H](CN(S(=O)(C3=CC=C(C=C3)N)=O)CC(C)C)O)CC4=CC=CC=C4)=O)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 54.77 100

Preparing Stock Solutions

The following data is based on the product molecular weight 547.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.13 mL 18.26 mL
5 mM 0.37 mL 1.83 mL 3.65 mL
10 mM 0.18 mL 0.91 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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References are publications that support the biological activity of the product.

Ghosh et al (1998) Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere. Bioorg.Med.Chem.Lett. 8 687 PMID: 9871583

Koh et al (2003) Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob.Agents Chemother. 47 3123 PMID: 14506019

If you know of a relevant reference for Darunavir, please let us know.

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