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Highly potent HIV protease inhibitor (IC50 = 3 - 6 nM, depending on laboratory HIV-1 strain). Displays activity in cells infected with clinical HIV-1 strains shown to have resistance to other protease inhibitors. Molecular modeling predicts binding to papain-like protease (PLpro) of SARS-CoV-2.
Tocris products are for biomedical research use only. They are not intended for human or veterinary use.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 547.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.83 mL||9.13 mL||18.26 mL|
|5 mM||0.37 mL||1.83 mL||3.65 mL|
|10 mM||0.18 mL||0.91 mL||1.83 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
References are publications that support the biological activity of the product.
Ghosh et al (1998) Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere. Bioorg.Med.Chem.Lett. 8 687 PMID: 9871583
Koh et al (2003) Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob.Agents Chemother. 47 3123 PMID: 14506019
Lin et al (2020) Molecular modeling evaluation of the binding effect of Ritonavir, Lopinavir and Darunavir to severe acute respiratory syndrome coronavirus 2 proteases. BioRxiv - Paper not yet peer reviewed
If you know of a relevant reference for Darunavir, please let us know.
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Citations for Darunavir
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Reviews for Darunavir
Average Rating: 5 (Based on 1 Review.)
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Interaction of darunavir was studied with the stable portion of the protease. It was an attempt to finally identify interactions with HIV-1 protease and to be more resistant against HIV-1 protease mutations.
Literature in this Area
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